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Mendeley readers
Attention Score in Context
| Title |
Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss
|
|---|---|
| Published in |
Cancer Cell International, February 2014
|
| DOI | 10.1186/1475-2867-14-13 |
| Pubmed ID | |
| Authors |
Pablo César Ortiz-Lazareno, Alejandro Bravo-Cuellar, José Manuel Lerma-Díaz, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, Jorge Ramiro Domínguez-Rodríguez, Oscar González-Ramella, Ruth De Célis, Paulina Gómez-Lomelí, Georgina Hernández-Flores |
| Abstract |
The resistance of cancerous cells to chemotherapy remains the main limitation for cancer treatment at present. Doxorubicin (DOX) is a potent antitumor drug that activates the ubiquitin-proteasome system, but unfortunately it also activates the Nuclear factor kappa B (NF-кB) pathway leading to the promotion of tumor cell survival. MG132 is a drug that inhibits I kappa B degradation by the proteasome-avoiding activation of NF-кB. In this work, we studied the sensitizing effect of the MG132 proteasome inhibitor on the antitumor activity of DOX. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 45 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 24% |
| Researcher | 8 | 17% |
| Student > Ph. D. Student | 8 | 17% |
| Student > Bachelor | 6 | 13% |
| Professor | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 6 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 35% |
| Biochemistry, Genetics and Molecular Biology | 10 | 22% |
| Medicine and Dentistry | 6 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Physics and Astronomy | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 7 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2014.
All research outputs
#15,293,290
of 22,743,667 outputs
Outputs from Cancer Cell International
#820
of 1,792 outputs
Outputs of similar age
#189,511
of 307,189 outputs
Outputs of similar age from Cancer Cell International
#9
of 18 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,792 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,189 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.