Title |
Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways
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Published in |
BMC Infectious Diseases, December 2013
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DOI | 10.1186/1471-2334-13-587 |
Pubmed ID | |
Authors |
Amanda Farage Frade, Cristina Wide Pissetti, Barbara Maria Ianni, Bruno Saba, Hui Tzu Lin-Wang, Luciana Gabriel Nogueira, Ariana de Melo Borges, Paula Buck, Fabrício Dias, Monique Baron, Ludmila Rodrigues Pinto Ferreira, Andre Schmidt, José Antonio Marin-Neto, Mario Hirata, Marcelo Sampaio, Abílio Fragata, Alexandre Costa Pereira, Eduardo Donadi, Jorge Kalil, Virmondes Rodrigues, Edecio Cunha-Neto, Christophe Chevillard |
Abstract |
Chagas disease, caused by the protozoan Trypanosoma cruzi is endemic in Latin America. Thirty percent of infected individuals develop chronic Chagas cardiomyopathy (CCC), an inflammatory dilated cardiomyopathy that is, by far, the most important clinical consequence of T. cruzi infection. The others remain asymptomatic (ASY). A possible genetic component to disease progression was suggested by familial aggregation of cases and the association of markers of innate and adaptive immunity genes with CCC development. Migration of Th1-type T cells play a major role in myocardial damage. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 68 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 19% |
Researcher | 12 | 17% |
Professor | 7 | 10% |
Student > Bachelor | 7 | 10% |
Student > Ph. D. Student | 5 | 7% |
Other | 14 | 20% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 21% |
Immunology and Microbiology | 13 | 19% |
Medicine and Dentistry | 12 | 17% |
Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Environmental Science | 1 | 1% |
Other | 4 | 6% |
Unknown | 17 | 24% |