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Relatively frequent switching of transcription start sites during cerebellar development

Overview of attention for article published in BMC Genomics, June 2017
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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8 tweeters

Citations

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20 Dimensions

Readers on

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44 Mendeley
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Title
Relatively frequent switching of transcription start sites during cerebellar development
Published in
BMC Genomics, June 2017
DOI 10.1186/s12864-017-3834-z
Pubmed ID
Authors

Peter Zhang, Emmanuel Dimont, Thomas Ha, Douglas J. Swanson, Winston Hide, Dan Goldowitz

Abstract

Alternative transcription start site (TSS) usage plays important roles in transcriptional control of mammalian gene expression. The growing interest in alternative TSSs and their role in genome diversification spawned many single-gene studies on differential usages of tissue-specific or temporal-specific alternative TSSs. However, exploration of the switching usage of alternative TSS usage on a genomic level, especially in the central nervous system, is largely lacking. In this study, We have prepared a unique set of time-course data for the developing cerebellum, as part of the FANTOM5 consortium ( http://fantom.gsc.riken.jp/5/ ) that uses their innovative capturing of 5' ends of all transcripts followed by Helicos next generation sequencing. We analyzed the usage of all transcription start sites (TSSs) at each time point during cerebellar development that provided information on multiple RNA isoforms that emerged from the same gene. We developed a mathematical method that systematically compares the expression of different TSSs of a gene to identify temporal crossover and non-crossover switching events. We identified 48,489 novel TSS switching events in 5433 genes during cerebellar development. This includes 9767 crossover TSS switching events in 1511 genes, where the dominant TSS shifts over time. We observed a relatively high prevalence of TSS switching in cerebellar development where the resulting temporally-specific gene transcripts and protein products can play important regulatory and functional roles.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 30%
Student > Master 6 14%
Student > Bachelor 6 14%
Other 4 9%
Researcher 3 7%
Other 6 14%
Unknown 6 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 45%
Agricultural and Biological Sciences 6 14%
Computer Science 3 7%
Neuroscience 3 7%
Engineering 2 5%
Other 2 5%
Unknown 8 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2017.
All research outputs
#4,278,562
of 16,235,274 outputs
Outputs from BMC Genomics
#2,071
of 8,975 outputs
Outputs of similar age
#81,151
of 273,303 outputs
Outputs of similar age from BMC Genomics
#3
of 7 outputs
Altmetric has tracked 16,235,274 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 8,975 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,303 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.