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Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs

Overview of attention for article published in Journal of Translational Medicine, February 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

twitter
4 tweeters
patent
12 patents

Citations

dimensions_citation
125 Dimensions

Readers on

mendeley
176 Mendeley

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Summary Twitter Patents Dimensions citations
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Title
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
Published in
Journal of Translational Medicine, February 2014
DOI 10.1186/1479-5876-12-36
Pubmed ID
24502656
Authors

Lei Lu, Xiaobing Xu, Bin Zhang, Rongsheng Zhang, Hongzan Ji, Xuan Wang

Abstract

The coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer hijack this pathway to escape from immune attack. The costimulatory receptor glucocorticoid-induced TNFR related protein (GITR) is up-regulated on activated T cells and increases their proliferation, activation and cytokine production. We hypothesize that concomitant PD-1 blockade and GITR triggering would synergistically improve the effector functions of tumor-infiltrating T cells and increase the antitumor immunity. In present study, we evaluated the antitumor effects and mechanisms of combined PD-1 blockade and GITR triggering in a clinically highly relevant murine ID8 ovarian cancer model.

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Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
France 1 <1%
Netherlands 1 <1%
Belgium 1 <1%
Uruguay 1 <1%
Unknown 169 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 52 30%
Student > Ph. D. Student 35 20%
Student > Master 21 12%
Other 18 10%
Student > Bachelor 9 5%
Other 23 13%
Unknown 18 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 28%
Medicine and Dentistry 41 23%
Immunology and Microbiology 23 13%
Biochemistry, Genetics and Molecular Biology 20 11%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 13 7%
Unknown 24 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2022.
All research outputs
#1,482,743
of 21,685,809 outputs
Outputs from Journal of Translational Medicine
#242
of 3,751 outputs
Outputs of similar age
#18,590
of 289,353 outputs
Outputs of similar age from Journal of Translational Medicine
#5
of 63 outputs
Altmetric has tracked 21,685,809 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,751 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,353 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.

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