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Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs

Overview of attention for article published in Journal of Translational Medicine, February 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

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4 X users
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15 patents

Citations

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146 Dimensions

Readers on

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197 Mendeley
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Title
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
Published in
Journal of Translational Medicine, February 2014
DOI 10.1186/1479-5876-12-36
Pubmed ID
Authors

Lei Lu, Xiaobing Xu, Bin Zhang, Rongsheng Zhang, Hongzan Ji, Xuan Wang

Abstract

The coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer hijack this pathway to escape from immune attack. The costimulatory receptor glucocorticoid-induced TNFR related protein (GITR) is up-regulated on activated T cells and increases their proliferation, activation and cytokine production. We hypothesize that concomitant PD-1 blockade and GITR triggering would synergistically improve the effector functions of tumor-infiltrating T cells and increase the antitumor immunity. In present study, we evaluated the antitumor effects and mechanisms of combined PD-1 blockade and GITR triggering in a clinically highly relevant murine ID8 ovarian cancer model.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
France 1 <1%
Netherlands 1 <1%
Belgium 1 <1%
Uruguay 1 <1%
Unknown 190 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 54 27%
Student > Ph. D. Student 39 20%
Student > Master 22 11%
Other 18 9%
Student > Bachelor 13 7%
Other 24 12%
Unknown 27 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 25%
Medicine and Dentistry 48 24%
Biochemistry, Genetics and Molecular Biology 22 11%
Immunology and Microbiology 22 11%
Pharmacology, Toxicology and Pharmaceutical Science 6 3%
Other 17 9%
Unknown 32 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2023.
All research outputs
#1,870,993
of 25,559,053 outputs
Outputs from Journal of Translational Medicine
#341
of 4,672 outputs
Outputs of similar age
#21,012
of 323,280 outputs
Outputs of similar age from Journal of Translational Medicine
#3
of 75 outputs
Altmetric has tracked 25,559,053 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,672 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,280 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.