Title |
Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome: a randomized double -blind control trial
|
---|---|
Published in |
Lipids in Health and Disease, June 2017
|
DOI | 10.1186/s12944-017-0504-8 |
Pubmed ID | |
Authors |
Sonal Gupta Jain, Seema Puri, Anoop Misra, Seema Gulati, Kalaivani Mani |
Abstract |
Nutritional modulation remains central to the management of metabolic syndrome. Intervention with cinnamon in individuals with metabolic syndrome remains sparsely researched. We investigated the effect of oral cinnamon consumption on body composition and metabolic parameters of Asian Indians with metabolic syndrome. In this 16-week double blind randomized control trial, 116 individuals with metabolic syndrome were randomized to two dietary intervention groups, cinnamon [6 capsules (3 g) daily] or wheat flour [6 capsules (2.5 g) daily]. Body composition, blood pressure and metabolic parameters were assessed. Significantly greater decrease [difference between means, (95% CI)] in fasting blood glucose (mmol/L) [0.3 (0.2, 0.5) p = 0.001], glycosylated haemoglobin (mmol/mol) [2.6 (0.4, 4.9) p = 0.023], waist circumference (cm) [4.8 (1.9, 7.7) p = 0.002] and body mass index (kg/m2 ) [1.3 (0.9, 1.5) p = 0.001] was observed in the cinnamon group compared to placebo group. Other parameters which showed significantly greater improvement were: waist-hip ratio, blood pressure, serum total cholesterol, low-density lipoprotein cholesterol, serum triglycerides, and high-density lipoprotein cholesterol. Prevalence of defined metabolic syndrome was significantly reduced in the intervention group (34.5%) vs. the placebo group (5.2%). A single supplement intervention with 3 g cinnamon for 16 weeks resulted in significant improvements in all components of metabolic syndrome in a sample of Asian Indians in north India. The clinical trial was retrospectively registered (after the recruitment of the participants) in ClinicalTrial.gov under the identification number: NCT02455778 on 25th May 2015. |
Twitter Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 6 | 23% |
United States | 3 | 12% |
United Kingdom | 2 | 8% |
Germany | 1 | 4% |
Sri Lanka | 1 | 4% |
Uruguay | 1 | 4% |
Mexico | 1 | 4% |
New Zealand | 1 | 4% |
Unknown | 10 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 17 | 65% |
Practitioners (doctors, other healthcare professionals) | 6 | 23% |
Scientists | 2 | 8% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 206 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 33 | 16% |
Student > Master | 25 | 12% |
Researcher | 19 | 9% |
Student > Ph. D. Student | 18 | 9% |
Student > Postgraduate | 10 | 5% |
Other | 33 | 16% |
Unknown | 68 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 49 | 24% |
Nursing and Health Professions | 36 | 17% |
Agricultural and Biological Sciences | 14 | 7% |
Biochemistry, Genetics and Molecular Biology | 8 | 4% |
Chemistry | 7 | 3% |
Other | 14 | 7% |
Unknown | 78 | 38% |