Title |
Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits
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Published in |
Neural Development, February 2014
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DOI | 10.1186/1749-8104-9-2 |
Pubmed ID | |
Authors |
Jason W Triplett, Wei Wei, Cristina Gonzalez, Neal T Sweeney, Andrew D Huberman, Marla B Feller, David A Feldheim |
Abstract |
There are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene. This functional specificity is derived from distinct RGC morphologies and selective synapse formation with other retinal cell types; yet, how these properties are established during development remains unclear. Islet2 (Isl2) is a LIM-homeodomain transcription factor expressed in the developing retina, including approximately 40% of all RGCs, and has previously been implicated in the subtype specification of spinal motor neurons. Based on this, we hypothesized that Isl2+ RGCs represent a related subset that share a common function. |
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