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Most children with cancer are not enrolled on a clinical trial in Canada: a population-based study

Overview of attention for article published in BMC Cancer, June 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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35 Mendeley
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Title
Most children with cancer are not enrolled on a clinical trial in Canada: a population-based study
Published in
BMC Cancer, June 2017
DOI 10.1186/s12885-017-3390-6
Pubmed ID
Authors

Jason D. Pole, Randy Barber, Rose-Émilie Bergeron, Anne Sophie Carret, David Dix, Ketan Kulkarni, Emilie Martineau, Alicia Randall, David Stammers, Caron Strahlendorf, Douglas R. Strother, Tony H. Truong, Lillian Sung

Abstract

Primary objective was to describe the proportion of children newly diagnosed with cancer enrolled on a therapeutic clinical trial. Secondary objectives were to describe reasons for non-enrollment and factors associated with enrollment on trials. In this retrospective cohort study, we included children newly diagnosed with cancer between 0 and 14 years of age and diagnosed from 2001 to 2012. We used data from the Cancer in Young People in Canada (CYP-C) national pediatric cancer population-based database. CYP-C captures all cases of pediatric cancer (0-14 years) diagnosed and treated at one of the 17 tertiary pediatric oncology centers in Canada. Non-enrollment was evaluated using univariate and multiple logistic regression analysis. There were 9204 children with cancer included, of whom 2533 (27.5%) were enrolled on a clinical trial. The most common reasons cited for non-enrollment were lack of an available trial (52.2%) and physician choice (11.2%). In multiple regression, Asian and Arab/west Asian race were associated with lower enrollment (P = 0.006 and P = 0.032 respectively). All cancer diagnoses were more likely to be enrolled compared to astrocytoma and children with acute lymphoblastic leukemia had an almost 18-fold increased odds of enrollment compared to astrocytoma (P < 0.0001). Greater distance from the tertiary care center was independently associated with non-enrollment (P < 0.0001). In Canada, 27.5% of children with cancer are enrolled onto therapeutic clinical trials and lack of an available trial is the most common reason contributing to non-enrollment. Future research should better understand reasons for lack of trial availability and physician preferences to not offer trials.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 20%
Student > Ph. D. Student 6 17%
Student > Bachelor 3 9%
Student > Master 3 9%
Lecturer 1 3%
Other 4 11%
Unknown 11 31%
Readers by discipline Count As %
Medicine and Dentistry 8 23%
Psychology 5 14%
Nursing and Health Professions 3 9%
Social Sciences 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 3 9%
Unknown 12 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2021.
All research outputs
#2,843,060
of 22,981,247 outputs
Outputs from BMC Cancer
#597
of 8,350 outputs
Outputs of similar age
#54,704
of 317,198 outputs
Outputs of similar age from BMC Cancer
#14
of 127 outputs
Altmetric has tracked 22,981,247 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,350 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,198 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.