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Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms

Overview of attention for article published in BMC Psychiatry, June 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)

Mentioned by

news
6 news outlets
twitter
31 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page
reddit
1 Redditor
video
1 video uploader

Citations

dimensions_citation
61 Dimensions

Readers on

mendeley
309 Mendeley
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Title
Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms
Published in
BMC Psychiatry, June 2017
DOI 10.1186/s12888-017-1383-2
Pubmed ID
Authors

Nadia Cattane, Roberta Rossi, Mariangela Lanfredi, Annamaria Cattaneo

Abstract

According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability. We prove the role of alterations in Hypothalamic-Pituitary-Adrenal (HPA) axis, in neurotrasmission, in the endogenous opioid system and in neuroplasticity in the childhood trauma-associated vulnerability to develop BPD; we also confirm the presence of morphological changes in several BPD brain areas and in particular in those involved in stress response. Not so many studies are available on epigenetic changes in BPD patients, although these mechanisms are widely investigated in relation to stress-related disorders. A better comprehension of the biological and epigenetic mechanisms, affected by childhood trauma and altered in BPD patients, could allow to identify "at high risk" subjects and to prevent or minimize the development of the disease later in life.

Twitter Demographics

The data shown below were collected from the profiles of 31 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 309 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 309 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 69 22%
Student > Master 39 13%
Student > Ph. D. Student 29 9%
Student > Doctoral Student 24 8%
Researcher 22 7%
Other 53 17%
Unknown 73 24%
Readers by discipline Count As %
Psychology 108 35%
Medicine and Dentistry 44 14%
Social Sciences 15 5%
Nursing and Health Professions 15 5%
Neuroscience 13 4%
Other 30 10%
Unknown 84 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 82. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2021.
All research outputs
#366,457
of 20,122,740 outputs
Outputs from BMC Psychiatry
#83
of 4,130 outputs
Outputs of similar age
#8,071
of 238,541 outputs
Outputs of similar age from BMC Psychiatry
#1
of 1 outputs
Altmetric has tracked 20,122,740 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,130 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,541 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them