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A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection

Overview of attention for article published in Genome Biology, February 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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28 X users
weibo
1 weibo user
facebook
1 Facebook page

Citations

dimensions_citation
244 Dimensions

Readers on

mendeley
310 Mendeley
citeulike
5 CiteULike
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Title
A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection
Published in
Genome Biology, February 2014
DOI 10.1186/gb-2014-15-2-r34
Pubmed ID
Authors

Steve Hoffmann, Christian Otto, Gero Doose, Andrea Tanzer, David Langenberger, Sabina Christ, Manfred Kunz, Lesca M Holdt, Daniel Teupser, Jörg Hackermüller, Peter F Stadler

Abstract

Numerous high-throughput sequencing studies focus on detecting conventionally spliced mRNAs in RNA-seq data. However, non-standard RNAs arising through gene fusion, circularization, or trans-splicing are often neglected. We introduce a novel, unbiased algorithm to detect splice junctions from single-end cDNA sequences. In contrast to other methods, our approach accommodates multi-junction structures. Our method compares favorably with competing tools on conventionally spliced mRNAs and, with a gain of up to 40\% of recall, systematically outperforms them on reads with multiple splits, trans-splicing and circular products. The algorithm is integrated into our mapping tool segemehl (www.bioinf.uni-leipzig.de/Software/segemehl/).

X Demographics

X Demographics

The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 310 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
Germany 3 <1%
United Kingdom 3 <1%
Denmark 2 <1%
Brazil 2 <1%
Ireland 1 <1%
Italy 1 <1%
Netherlands 1 <1%
Switzerland 1 <1%
Other 6 2%
Unknown 284 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 87 28%
Researcher 73 24%
Student > Master 35 11%
Student > Bachelor 23 7%
Professor > Associate Professor 17 5%
Other 34 11%
Unknown 41 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 122 39%
Biochemistry, Genetics and Molecular Biology 74 24%
Computer Science 24 8%
Medicine and Dentistry 17 5%
Engineering 7 2%
Other 17 5%
Unknown 49 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2020.
All research outputs
#2,169,294
of 25,706,302 outputs
Outputs from Genome Biology
#1,802
of 4,504 outputs
Outputs of similar age
#24,929
of 329,533 outputs
Outputs of similar age from Genome Biology
#50
of 96 outputs
Altmetric has tracked 25,706,302 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,504 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,533 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.