Title |
Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer
|
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Published in |
BMC Biophysics, February 2014
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DOI | 10.1186/2046-1682-7-1 |
Pubmed ID | |
Authors |
Yang Liu, Shikhar Uttam, Sergey Alexandrov, Rajan K Bista |
Abstract |
The cell and tissue structural properties assessed with a conventional bright-field light microscope play a key role in cancer diagnosis, but they sometimes have limited accuracy in detecting early-stage cancers or predicting future risk of cancer progression for individual patients (i.e., prognosis) if no frank cancer is found. The recent development in optical microscopy techniques now permit the nanoscale structural imaging and quantitative structural analysis of tissue and cells, which offers a new opportunity to investigate the structural properties of cell and tissue below 200 - 250 nm as an early sign of carcinogenesis, prior to the presence of microscale morphological abnormalities. Identification of nanoscale structural signatures is significant for earlier and more accurate cancer detection and prognosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 7% |
Iran, Islamic Republic of | 1 | 3% |
Uruguay | 1 | 3% |
Unknown | 26 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 30% |
Researcher | 6 | 20% |
Student > Doctoral Student | 5 | 17% |
Student > Master | 3 | 10% |
Lecturer | 2 | 7% |
Other | 2 | 7% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 9 | 30% |
Agricultural and Biological Sciences | 5 | 17% |
Physics and Astronomy | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Medicine and Dentistry | 2 | 7% |
Other | 2 | 7% |
Unknown | 5 | 17% |