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Early-life gut microbial colonization shapes Th1/Th2 balance in asthma model in BALB/c mice

Overview of attention for article published in BMC Microbiology, June 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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2 blogs
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Title
Early-life gut microbial colonization shapes Th1/Th2 balance in asthma model in BALB/c mice
Published in
BMC Microbiology, June 2017
DOI 10.1186/s12866-017-1044-0
Pubmed ID
Authors

Li-Juan Qian, Shu-Min Kang, Jia-Li Xie, Li Huang, Quan Wen, Yuan-Yuan Fan, Li-Jun Lu, Li Jiang

Abstract

We aimed to investigate the effect of early-life diverse microbial exposures on gut microbial colonization in an OVA-induced asthma model in BALB/c mice. BALB/c mice were divided into 4 groups: A, offsprings were kept in a SPF environment during fetal, lactation, and childhood periods; B, offsprings were kept in the SPF environment during fetal and lactation periods, and kept in the general environment during childhood; C, offsprings were kept in the SPF environment only during fetal period, and then kept in the general environment; and D, offsprings were kept in the general environment during whole periods. The diversity of intestinal flora was analyzed using denaturing gradient gel electrophoresis. Mice were sensitized with OVA to establish an animal model of asthma. Then asthma-related inflammatory cytokines and histological analysis were performed. The diversity of intestinal microflora in group D was significantly higher than groups A, B and C at three days and three weeks after birth, and the diversity of intestinal microflora in groups C and D were significantly higher than groups A and B at five weeks after birth. The pathologic scores of OVA-induced asthmatic mice in group D were significantly lower than group A, and serum IFN-γ levels and the IFN-γ/IL-4 ratio in group D were significantly higher than group A. Exposure to diverse microbial environments in early life affects gut microbial colonization in BALB/c mice. The diversity of the intestinal flora in early life may prevent airway inflammation in asthma via regulating the Th1/Th2 balance.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 20%
Student > Ph. D. Student 7 13%
Student > Master 5 9%
Researcher 4 7%
Other 3 6%
Other 9 17%
Unknown 15 28%
Readers by discipline Count As %
Immunology and Microbiology 9 17%
Agricultural and Biological Sciences 8 15%
Biochemistry, Genetics and Molecular Biology 6 11%
Medicine and Dentistry 5 9%
Nursing and Health Professions 4 7%
Other 6 11%
Unknown 16 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2018.
All research outputs
#2,108,123
of 22,981,247 outputs
Outputs from BMC Microbiology
#138
of 3,206 outputs
Outputs of similar age
#42,769
of 316,926 outputs
Outputs of similar age from BMC Microbiology
#5
of 64 outputs
Altmetric has tracked 22,981,247 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,206 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,926 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.