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Variation in susceptibility of different breeds of sheep to Mycobacterium avium subspecies paratuberculosis following experimental inoculation

Overview of attention for article published in Veterinary Research, June 2017
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  • Good Attention Score compared to outputs of the same age (67th percentile)

Mentioned by

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7 tweeters

Citations

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13 Dimensions

Readers on

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40 Mendeley
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Title
Variation in susceptibility of different breeds of sheep to Mycobacterium avium subspecies paratuberculosis following experimental inoculation
Published in
Veterinary Research, June 2017
DOI 10.1186/s13567-017-0440-7
Pubmed ID
Authors

D. J. Begg, A. C. Purdie, K. de Silva, N. K. Dhand, K. M. Plain, R. J. Whittington

Abstract

Exposure to Mycobacterium avium subspecies paratuberculosis (MAP) does not always lead to Johne's disease. Understanding differences in disease susceptibility of individual animals is a key aspect to controlling mycobacterial diseases. This study was designed to examine the susceptibility or resistance of various breeds of sheep to MAP infection. Merino, Suffolk first cross Merino, Border Leicester, and Poll Dorset sheep were orally inoculated with MAP and monitored for 14 months. Clinical disease occurred more frequently in the Merino (42%) and Suffolk first cross Merino (36%) compared to the Border Leicester (12%) and Poll Dorset (11%) breeds. Infection risk, as determined by culture of gut and associated lymphoid tissues, ranged from 75% for the Suffolk first cross Merino to 47% for the Poll Dorset sheep. Significant differences were identified in the site in the intestines of the most severe histopathological lesions and the immune responses to infection between the breeds. However, there was no difference in faecal MAP shedding by clinical cases between breeds. All breeds tested were susceptible to MAP infection, as determined by infection and clinical disease development, although there were differences in the proportions of diseased animals between the breeds. Poll Dorset and Border Leicester sheep were more resilient to MAP infection but there was evidence that more animals could have developed disease if given more time. These findings provide evidence of potential differential disease susceptibility between breeds, further our understanding of disease pathogenesis and risks of disease spread, and may have an influence on control programs for paratuberculosis.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 20%
Researcher 8 20%
Student > Master 6 15%
Student > Doctoral Student 3 8%
Professor > Associate Professor 3 8%
Other 8 20%
Unknown 4 10%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 16 40%
Agricultural and Biological Sciences 7 18%
Immunology and Microbiology 3 8%
Biochemistry, Genetics and Molecular Biology 2 5%
Business, Management and Accounting 1 3%
Other 3 8%
Unknown 8 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2017.
All research outputs
#4,542,184
of 15,916,110 outputs
Outputs from Veterinary Research
#218
of 959 outputs
Outputs of similar age
#87,308
of 270,278 outputs
Outputs of similar age from Veterinary Research
#1
of 2 outputs
Altmetric has tracked 15,916,110 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 959 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,278 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them