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Aggressive natural killer cell leukemia or extranodal NK/T cell lymphoma? a case with nasal involvement

Overview of attention for article published in Diagnostic Pathology, June 2017
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Title
Aggressive natural killer cell leukemia or extranodal NK/T cell lymphoma? a case with nasal involvement
Published in
Diagnostic Pathology, June 2017
DOI 10.1186/s13000-017-0636-1
Pubmed ID
Authors

Xiaoke Jin, Youhai Xu, Jun Zhang, Guangxi Li, Dongping Huang, Yuqiong Yang, Hesheng He

Abstract

Aggressive natural killer cell leukemia/lymphoma (ANKL) is a rare and highly aggressive NK cell neoplasm with a short clinical course and poor prognosis and is often misdiagnosed and confused with NK/T cell lymphoma (NKTL), which has a very different prognosis. Here, we present a case with nasal and bone marrow involvement, provide a literature review and make a differential diagnosis. A 41-year-old male presented nasal congestion pharyngalgia, palatal perforation, high fever and multiorgan dysfunction. Our diagnosis primarily relied on clinical features, the morphology and immunophenotype of the neoplastic cells and imaging studies. Characteristic large granular lymphocytes with azurophilic granules were visible in the bone marrow smears. In addition, the neoplastic cells expressed a typical immunophenotype, and the T cell receptor γ (TCR-γ) gene rearrangement analysis and presence of Epstein-Barr virus (EBV) were negative. The patient's symptoms and signs were temporarily relieved after chemotherapy treatment, but after a short time, he underwent a rapid clinical decline and died 8 weeks later after admission due to multiorgan function failure. Our case demonstrates that to avoid a misdiagnosis, bone marrow analyses and other examinations should be performed early when a patient initially presents nasal lesions and other systemic symptoms. To the best of our knowledge, this may be the first reported case of ANKL with sternal tenderness.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 17%
Student > Ph. D. Student 2 11%
Lecturer > Senior Lecturer 1 6%
Student > Master 1 6%
Student > Postgraduate 1 6%
Other 0 0%
Unknown 10 56%
Readers by discipline Count As %
Medicine and Dentistry 4 22%
Biochemistry, Genetics and Molecular Biology 2 11%
Chemistry 1 6%
Unknown 11 61%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2017.
All research outputs
#18,555,330
of 22,981,247 outputs
Outputs from Diagnostic Pathology
#761
of 1,135 outputs
Outputs of similar age
#241,820
of 316,926 outputs
Outputs of similar age from Diagnostic Pathology
#8
of 12 outputs
Altmetric has tracked 22,981,247 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,135 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.