Title |
A procedure to characterize geographic distributions of rare disorders in cohorts
|
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Published in |
International Journal of Health Geographics, May 2008
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DOI | 10.1186/1476-072x-7-26 |
Pubmed ID | |
Authors |
Karla C Van Meter, Lasse E Christiansen, Irva Hertz-Picciotto, Rahman Azari, Tim E Carpenter |
Abstract |
Individual point data can be analyzed against an entire cohort instead of only sampled controls to accurately picture the geographic distribution of populations at risk for low prevalence diseases. Analyzed as individual points, many smaller clusters with high relative risks (RR) and low empirical p values are indistinguishable from a random distribution. When points are aggregated into areal units, small clusters may result in a larger cluster with a low RR or be lost if divided into pieces included in units of larger populations that show no increased prevalence. Previous simulation studies showed lowered validity of spatial scan tests for true clusters with low RR. Using simulations, this study explored the effects of low cluster RR and areal unit size on local area clustering test (LACT) results, proposing a procedure to improve accuracy of cohort spatial analysis for rare events. |
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Geographical breakdown
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Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 36% |
Lecturer | 2 | 14% |
Professor | 2 | 14% |
Professor > Associate Professor | 2 | 14% |
Student > Ph. D. Student | 1 | 7% |
Other | 1 | 7% |
Unknown | 1 | 7% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 43% |
Social Sciences | 2 | 14% |
Mathematics | 1 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Nursing and Health Professions | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |