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Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo

Overview of attention for article published in BMC Cancer, February 2014
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Mentioned by

twitter
2 tweeters

Citations

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42 Dimensions

Readers on

mendeley
58 Mendeley
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Title
Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo
Published in
BMC Cancer, February 2014
DOI 10.1186/1471-2407-14-90
Pubmed ID
Authors

Zhihong Chen, Lora W Forman, Robert M Williams, Douglas V Faller

Abstract

A subpopulation of tumor cells with distinct stem-like properties (cancer stem-like cells, CSCs) may be responsible for tumor initiation, invasive growth, and possibly dissemination to distant organ sites. CSCs exhibit a spectrum of biological, biochemical, and molecular features that are consistent with a stem-like phenotype, including growth as non-adherent spheres (clonogenic potential), ability to form a new tumor in xenograft assays, unlimited self-renewal, and the capacity for multipotency and lineage-specific differentiation. PKCδ is a novel class serine/threonine kinase of the PKC family, and functions in a number of cellular activities including cell proliferation, survival or apoptosis. PKCδ has previously been validated as a synthetic lethal target in cancer cells of multiple types with aberrant activation of Ras signaling, using both genetic (shRNA and dominant-negative PKCδ mutants) and small molecule inhibitors. In contrast, PKCδ is not required for the proliferation or survival of normal cells, suggesting the potential tumor-specificity of a PKCδ-targeted approach.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 22%
Student > Ph. D. Student 12 21%
Researcher 9 16%
Student > Master 5 9%
Professor > Associate Professor 4 7%
Other 7 12%
Unknown 8 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 26%
Agricultural and Biological Sciences 14 24%
Medicine and Dentistry 8 14%
Chemistry 4 7%
Nursing and Health Professions 1 2%
Other 4 7%
Unknown 12 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#7,762,274
of 12,372,945 outputs
Outputs from BMC Cancer
#2,228
of 4,558 outputs
Outputs of similar age
#99,210
of 190,232 outputs
Outputs of similar age from BMC Cancer
#17
of 36 outputs
Altmetric has tracked 12,372,945 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,558 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,232 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.