Title |
Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shhin the diencephalon in vertebrates
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Published in |
BMC Biology, February 2014
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DOI | 10.1186/1741-7007-12-13 |
Pubmed ID | |
Authors |
Mallika Chatterjee, Qiuxia Guo, Sabrina Weber, Steffen Scholpp, James YH Li |
Abstract |
The habenula and the thalamus are two critical nodes in the forebrain circuitry and they connect the midbrain and the cerebral cortex in vertebrates. The habenula is derived from the epithalamus and rests dorsally to the thalamus. Both epithalamus and thalamus arise from a single diencephalon segment called prosomere (p)2. Shh is expressed in the ventral midline of the neural tube and in the mid-diencephalic organizer (MDO) at the zona limitans intrathalamica between thalamus and prethalamus. Acting as a morphogen, Shh plays an important role in regulating cell proliferation and survival in the diencephalon and thalamic patterning. The molecular regulation of the MDO Shh expression and the potential role of Shh in development of the habenula remain largely unclear. |
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United Kingdom | 1 | 25% |
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Demographic breakdown
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Scientists | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
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France | 1 | 1% |
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Researcher | 9 | 13% |
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Professor > Associate Professor | 5 | 7% |
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Unknown | 9 | 13% |
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Arts and Humanities | 1 | 1% |
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