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Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shhin the diencephalon in vertebrates

Overview of attention for article published in BMC Biology, February 2014
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Title
Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shhin the diencephalon in vertebrates
Published in
BMC Biology, February 2014
DOI 10.1186/1741-7007-12-13
Pubmed ID
Authors

Mallika Chatterjee, Qiuxia Guo, Sabrina Weber, Steffen Scholpp, James YH Li

Abstract

The habenula and the thalamus are two critical nodes in the forebrain circuitry and they connect the midbrain and the cerebral cortex in vertebrates. The habenula is derived from the epithalamus and rests dorsally to the thalamus. Both epithalamus and thalamus arise from a single diencephalon segment called prosomere (p)2. Shh is expressed in the ventral midline of the neural tube and in the mid-diencephalic organizer (MDO) at the zona limitans intrathalamica between thalamus and prethalamus. Acting as a morphogen, Shh plays an important role in regulating cell proliferation and survival in the diencephalon and thalamic patterning. The molecular regulation of the MDO Shh expression and the potential role of Shh in development of the habenula remain largely unclear.

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The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Chile 1 1%
Brazil 1 1%
France 1 1%
Spain 1 1%
South Africa 1 1%
Unknown 61 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 22%
Student > Bachelor 11 16%
Researcher 9 13%
Student > Master 8 12%
Professor > Associate Professor 5 7%
Other 11 16%
Unknown 9 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 38%
Biochemistry, Genetics and Molecular Biology 14 21%
Neuroscience 12 18%
Medicine and Dentistry 2 3%
Arts and Humanities 1 1%
Other 4 6%
Unknown 9 13%