Title |
Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice
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Published in |
BMC Genomics, February 2014
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DOI | 10.1186/1471-2164-15-131 |
Pubmed ID | |
Authors |
Pankaj Chopra, Ligia A Papale, Andrew T J White, Andrea Hatch, Ryan M Brown, Mark A Garthwaite, Patrick H Roseboom, Thaddeus G Golos, Stephen T Warren, Reid S Alisch |
Abstract |
Methylation on the fifth position of cytosine (5-mC) is an essential epigenetic mark that is linked to both normal neurodevelopment and neurological diseases. The recent identification of another modified form of cytosine, 5-hydroxymethylcytosine (5-hmC), in both stem cells and post-mitotic neurons, raises new questions as to the role of this base in mediating epigenetic effects. Genomic studies of these marks using model systems are limited, particularly with array-based tools, because the standard method of detecting DNA methylation cannot distinguish between 5-mC and 5-hmC and most methods have been developed to only survey the human genome. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 17% |
Venezuela, Bolivarian Republic of | 1 | 17% |
Spain | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Scientists | 2 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 4% |
United Kingdom | 1 | 1% |
Unknown | 64 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 26% |
Researcher | 17 | 25% |
Student > Master | 9 | 13% |
Student > Bachelor | 5 | 7% |
Student > Doctoral Student | 5 | 7% |
Other | 6 | 9% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 26 | 38% |
Biochemistry, Genetics and Molecular Biology | 14 | 21% |
Neuroscience | 5 | 7% |
Chemistry | 3 | 4% |
Computer Science | 3 | 4% |
Other | 9 | 13% |
Unknown | 8 | 12% |