Title |
A theoretical model of the West Nile Virus survival data
|
---|---|
Published in |
BMC Immunology, June 2017
|
DOI | 10.1186/s12865-017-0206-z |
Pubmed ID | |
Authors |
James K. Peterson, Alison M. Kesson, Nicholas J. C. King |
Abstract |
In this work, we develop a theoretical model that explains the survival data in West Nile Virus infection. We build a model based on three cell populations in an infected host; the collateral damage cells, the infected dividing cell, and the infected non-dividing cells. T cell-mediated lysis of each of these populations is dependent on the level of MHC-1 upregulation, which is different in the two infected cell populations, interferon-gamma and free virus levels. The model allows us to plot a measure of host health versus time for a range of initial viral doses and from that infer the dependence of minimal health versus viral dose. This inferred functional relationship between the minimal host health and viral dose is very similar to the data that has been collected for WNV survival curves under experimental conditions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 2 | 25% |
Researcher | 2 | 25% |
Student > Bachelor | 1 | 13% |
Other | 1 | 13% |
Student > Doctoral Student | 1 | 13% |
Other | 1 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 25% |
Immunology and Microbiology | 2 | 25% |
Computer Science | 1 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 13% |
Economics, Econometrics and Finance | 1 | 13% |
Other | 1 | 13% |