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How holobionts get sick—toward a unifying scheme of disease

Overview of attention for article published in Microbiome, June 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Citations

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62 Dimensions

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105 Mendeley
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Title
How holobionts get sick—toward a unifying scheme of disease
Published in
Microbiome, June 2017
DOI 10.1186/s40168-017-0281-7
Pubmed ID
Authors

Silvio D. Pitlik, Omry Koren

Abstract

All humans, animals, and plants are holobionts. Holobionts comprise the host and a myriad of interacting microorganisms-the microbiota. The hologenome encompasses the genome of the host plus the composite of all microbial genomes (the microbiome). In health, there is a fine-tuned and resilient equilibrium within the members of the microbiota and between them and the host. This relative stability is maintained by a high level of microbial diversity, a delicate bio-geographic distribution of microorganisms, and a sophisticated and intricate molecular crosstalk among the multiple components of the holobiont. Pathobionts are temporarily benign microbes with the potential, under modified ecosystem conditions, to become key players in disease. Pathobionts may be endogenous, living for prolonged periods of time inside or on the host, or exogenous, invading the host during opportunistic situations. In both cases, the end result is the transformation of the beneficial microbiome into a health-perturbing pathobiome. We hypothesize that probably all diseases of holobionts, acute or chronic, infectious or non-infectious, and regional or systemic, are characterized by a perturbation of the healthy microbiome into a diseased pathobiome.

X Demographics

X Demographics

The data shown below were collected from the profiles of 57 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Unknown 104 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 23%
Researcher 19 18%
Student > Postgraduate 9 9%
Student > Master 9 9%
Student > Doctoral Student 6 6%
Other 21 20%
Unknown 17 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 29%
Biochemistry, Genetics and Molecular Biology 11 10%
Immunology and Microbiology 10 10%
Medicine and Dentistry 7 7%
Environmental Science 6 6%
Other 16 15%
Unknown 25 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 98. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2022.
All research outputs
#423,455
of 25,137,221 outputs
Outputs from Microbiome
#107
of 1,725 outputs
Outputs of similar age
#9,079
of 321,818 outputs
Outputs of similar age from Microbiome
#6
of 39 outputs
Altmetric has tracked 25,137,221 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,818 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.