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Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum

Overview of attention for article published in Parasites & Vectors, June 2017
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Mentioned by

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2 tweeters

Citations

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5 Dimensions

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6 Mendeley
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Title
Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum
Published in
Parasites & Vectors, June 2017
DOI 10.1186/s13071-017-2250-1
Pubmed ID
Authors

Lin Chen, Donghui Zhang, Wenyue Zhang, Yuxiao Zhu, Min Hou, Bingya Yang, Zhipeng Xu, Minjun Ji, Guanling Wu

Abstract

The involvement of CD8(+)T cells in schistosomiasis is being increasingly appreciated, but the underlying mechanism is not well defined. In this study, we showed that the absence of Batf3 alleviated liver damage in Batf3 (-/-) mice infected with S. japonicum. We found alleviated liver granulomatous inflammation in Batf3 (-/-) mice with schistosomiasis japonica could not be attributed to the difference in schistosome egg or worm burden. The stronger Tc1 cell responses observed in Batf3 (-/-) mice suggested that the deletion of Batf3 resulted in more activation of CD8(+)T cells unexpectedly during the natural infection of schistosomes. We detected a small amount of CD8α(+) DCs in the spleen of Batf3 (-/-) mice at 9w post-infection. This small amount of newly generated CD8α(+) DCs might contribute to enhanced activation of CD8(+)T cells via cross-presentation and activation which then attenuate hepatic pathological damage found in Batf3 (-/-) mice. Our study provides evidence that Batf3 is associated with the immunoregulation of the liver granuloma formation, which may confer a new options for schistosomiasis treatment.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 33%
Unspecified 1 17%
Researcher 1 17%
Unknown 2 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 33%
Unspecified 1 17%
Immunology and Microbiology 1 17%
Unknown 2 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2017.
All research outputs
#6,533,643
of 11,415,522 outputs
Outputs from Parasites & Vectors
#1,348
of 2,847 outputs
Outputs of similar age
#126,768
of 263,074 outputs
Outputs of similar age from Parasites & Vectors
#79
of 130 outputs
Altmetric has tracked 11,415,522 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,847 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.