Title |
Autophagy and multidrug resistance in cancer
|
---|---|
Published in |
Cancer Communications, June 2017
|
DOI | 10.1186/s40880-017-0219-2 |
Pubmed ID | |
Authors |
Ying-Jie Li, Yu-He Lei, Nan Yao, Chen-Ran Wang, Nan Hu, Wen-Cai Ye, Dong-Mei Zhang, Zhe-Sheng Chen |
Abstract |
Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue. Autophagy, a self-degradative system, universally arises during the treatment of sensitive and MDR cancer. Autophagy can be a double-edged sword for MDR tumors: it participates in the development of MDR and protects cancer cells from chemotherapeutics but can also kill MDR cancer cells in which apoptosis pathways are inactive. Autophagy induced by anticancer drugs could also activate apoptosis signaling pathways in MDR cells, facilitating MDR reversal. Therefore, research on the regulation of autophagy to combat MDR is expanding and is becoming increasingly important. We summarize advanced studies of autophagy in MDR tumors, including the variable role of autophagy in MDR cancer cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 376 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 55 | 15% |
Student > Bachelor | 55 | 15% |
Student > Ph. D. Student | 36 | 10% |
Researcher | 33 | 9% |
Student > Doctoral Student | 21 | 6% |
Other | 34 | 9% |
Unknown | 142 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 102 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 32 | 9% |
Medicine and Dentistry | 29 | 8% |
Agricultural and Biological Sciences | 20 | 5% |
Immunology and Microbiology | 9 | 2% |
Other | 37 | 10% |
Unknown | 147 | 39% |