Title |
Argatroban for an alternative anticoagulant in HIT during ECMO
|
---|---|
Published in |
Journal of Intensive Care, June 2017
|
DOI | 10.1186/s40560-017-0235-y |
Pubmed ID | |
Authors |
Alain Rougé, Felix Pelen, Michel Durand, Carole Schwebel |
Abstract |
Extracorporeal membrane oxygenation (ECMO) have become more frequently used in daily ICU practice, heparin-induced thrombocytopenia (HIT) is a rare but life-threatening complication while on extracorporeal membrane oxygenation (ECMO). HIT confirmation directly impacts on anticoagulant strategy requiring no delay unfractionated heparin discontinuation to be replaced by alternative systemic anticoagulant treatment. We report two clinical cases of HIT occurring during ECMO in various settings with subsequent recovery with argatroban and provide literature review to help physicians treat HIT during ECMO in clinical daily practice. HIT during ECMO is uncommon, and despite the absence of recommendation, argatroban seems to be an appropriate and safe therapeutic option. Finally, there are not enough arguments favouring routine circuit change in the event of HIT during ECMO. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Vietnam | 1 | 20% |
Italy | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 14% |
Student > Ph. D. Student | 7 | 12% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 5 | 9% |
Student > Bachelor | 4 | 7% |
Other | 14 | 24% |
Unknown | 14 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 53% |
Nursing and Health Professions | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Unspecified | 1 | 2% |
Other | 4 | 7% |
Unknown | 14 | 24% |