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Glial contributions to neurodegeneration in tauopathies

Overview of attention for article published in Molecular Neurodegeneration, June 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

1 news outlet
4 tweeters


142 Dimensions

Readers on

318 Mendeley
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Glial contributions to neurodegeneration in tauopathies
Published in
Molecular Neurodegeneration, June 2017
DOI 10.1186/s13024-017-0192-x
Pubmed ID

Cheryl E. G. Leyns, David M. Holtzman


Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation of the tau protein into filamentous inclusions that can be found in neurons and glial cells. Activated microglia, astrocytes and elevated levels of proinflammatory molecules are also pathological hallmarks that are found in brain regions affected by tau pathology. There has been abundant research in recent years to understand the role of gliosis and neuroinflammation in neurodegenerative diseases, particularly in Alzheimer's disease (AD) which is the most common form of dementia. AD is a tauopathy characterized by both extracellular amyloid-β plaques in addition to intracellular neurofibrillary tangles and neuropil threads containing aggregated tau protein. Accumulating evidence suggests that neuroinflammation offers a possible mechanistic link between these pathologies. Additionally, there appears to be a role for neuroinflammation in aggravating tau pathology and neurodegeneration in tauopathies featuring tau deposits as the predominant pathological signature. In this review, we survey the literature regarding inflammatory mechanisms that may impact neurodegeneration in AD and related tauopathies. We consider a physical role for microglia in the spread of tau pathology as well as the non-cell autonomous effects of secreted proinflammatory cytokines, specifically interleukin 1 beta, interleukin 6, tumor necrosis factor alpha and complement proteins. These molecules appear to have direct effects on tau pathophysiology and overall neuronal health. They also indirectly impact neuronal homeostasis by altering glial function. We conclude by proposing a complex role for gliosis and neuroinflammation in accelerating the progression of AD and other tauopathies.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 318 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 318 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 88 28%
Researcher 49 15%
Student > Bachelor 36 11%
Student > Master 29 9%
Student > Doctoral Student 20 6%
Other 44 14%
Unknown 52 16%
Readers by discipline Count As %
Neuroscience 111 35%
Biochemistry, Genetics and Molecular Biology 44 14%
Agricultural and Biological Sciences 39 12%
Medicine and Dentistry 15 5%
Pharmacology, Toxicology and Pharmaceutical Science 12 4%
Other 31 10%
Unknown 66 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2019.
All research outputs
of 17,364,317 outputs
Outputs from Molecular Neurodegeneration
of 684 outputs
Outputs of similar age
of 274,683 outputs
Outputs of similar age from Molecular Neurodegeneration
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Altmetric has tracked 17,364,317 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 684 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,683 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them