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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effect of pomegranate extracts on brain antioxidant markers and cholinesterase activity in high fat-high fructose diet induced obesity in rat model
|
|---|---|
| Published in |
BMC Complementary Medicine and Therapies, June 2017
|
| DOI | 10.1186/s12906-017-1842-9 |
| Pubmed ID | |
| Authors |
Zahra Amri, Asma Ghorbel, Mouna Turki, Férièle Messadi Akrout, Fatma Ayadi, Abdelfateh Elfeki, Mohamed Hammami |
| Abstract |
To investigate beneficial effects of Pomegranate seeds oil (PSO), leaves (PL), juice (PJ) and (PP) on brain cholinesterase activity, brain oxidative stress and lipid profile in high-fat-high fructose diet (HFD) induced-obese rat. In vitro and in vivo cholinesterase activity, brain oxidative status, body and brain weight and plasma lipid profile were measured in control rats, HFD-fed rats and HFD-fed rats treated by PSO, PL, PJ and PP. In vitro study showed that PSO, PL, PP, PJ inhibited cholinesterase activity in dose dependant manner. PL extract displayed the highest inhibitory activity by IC50 of 151.85 mg/ml. For in vivo study, HFD regime induced a significant increase of cholinesterase activity in brain by 17.4% as compared to normal rats. However, the administration of PSO, PL, PJ and PP to HDF-rats decreased cholinesterase activity in brain respectively by 15.48%, 6.4%, 20% and 18.7% as compared to untreated HFD-rats. Moreover, HFD regime caused significant increase in brain stress, brain and body weight, and lipid profile disorders in blood. Furthermore, PSO, PL, PJ and PP modulated lipid profile in blood and prevented accumulation of lipid in brain and body evidenced by the decrease of their weights as compared to untreated HFD-rats. In addition administration of these extract protected brain from stress oxidant, evidenced by the decrease of malondialdehyde (MDA) and Protein carbonylation (PC) levels and the increase in superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. These findings highlight the neuroprotective effects of pomegranate extracts and one of mechanisms is the inhibition of cholinesterase and the stimulation of antioxidant capacity. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 19% |
| United Kingdom | 2 | 10% |
| Germany | 1 | 5% |
| Mexico | 1 | 5% |
| Netherlands | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 11 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 81% |
| Practitioners (doctors, other healthcare professionals) | 3 | 14% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 103 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 13% |
| Student > Bachelor | 12 | 12% |
| Researcher | 11 | 11% |
| Student > Ph. D. Student | 9 | 9% |
| Student > Doctoral Student | 7 | 7% |
| Other | 17 | 17% |
| Unknown | 34 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 13% |
| Agricultural and Biological Sciences | 11 | 11% |
| Biochemistry, Genetics and Molecular Biology | 10 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 9% |
| Neuroscience | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 39 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2022.
All research outputs
#846,953
of 25,243,918 outputs
Outputs from BMC Complementary Medicine and Therapies
#115
of 3,944 outputs
Outputs of similar age
#17,517
of 321,828 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#4
of 123 outputs
Altmetric has tracked 25,243,918 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,944 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.