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High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells

Overview of attention for article published in BMC Genomics, February 2014
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Mentioned by

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3 X users

Citations

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16 Dimensions

Readers on

mendeley
66 Mendeley
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1 CiteULike
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Title
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells
Published in
BMC Genomics, February 2014
DOI 10.1186/1471-2164-15-158
Pubmed ID
Authors

Michael Boettcher, Andrew Lawson, Viola Ladenburger, Johannes Fredebohm, Jonas Wolf, Jörg D Hoheisel, Christian Frezza, Tomer Shlomi

Abstract

Synthetic lethality is an appealing technique for selectively targeting cancer cells which have acquired molecular changes that distinguish them from normal cells. High-throughput RNAi-based screens have been successfully used to identify synthetic lethal pathways with well-characterized tumor suppressors and oncogenes. The recent identification of metabolic tumor suppressors suggests that the concept of synthetic lethality can be applied to selectively target cancer metabolism as well.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Iran, Islamic Republic of 1 2%
Germany 1 2%
Unknown 62 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 30%
Student > Ph. D. Student 11 17%
Student > Master 5 8%
Professor > Associate Professor 4 6%
Other 3 5%
Other 9 14%
Unknown 14 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 47%
Biochemistry, Genetics and Molecular Biology 12 18%
Medicine and Dentistry 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Economics, Econometrics and Finance 1 2%
Other 1 2%
Unknown 14 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#14,775,080
of 22,745,803 outputs
Outputs from BMC Genomics
#6,123
of 10,634 outputs
Outputs of similar age
#125,725
of 220,969 outputs
Outputs of similar age from BMC Genomics
#79
of 154 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,634 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 220,969 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 154 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.