@cremieuxrecueil Inbreeding causes many problems, but it also protects somewhat against malaria. When are the downsides of inbreeding greater than the upsides? I'm not sure. https://t.co/o7BoJWx6VB
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@SanjGhee @razibkhan 5) Selection by Malaria? Consanguinity and endogamy may have allowed recessive alleles for blood disorders to become fixed in populations where Malaria is endemic https://t.co/lJ07EoXnfG
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@gypsy_heart6 From evolutionary perspective, one hypothesis is cousin marriages in ME/South Asia/sub-saharan Africa allowed genes that minimize susceptability to Malaria to spread (e.g. alpha/beta thalassemia, sickle cell anemia) & favoured by natural
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@HawkesBay Paper that shows this using stochastic models integrating benefits of alpha thalassemia & costs on inbreeding here: https://t.co/7GwKShOJqw