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Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model

Overview of attention for article published in Stem Cell Research & Therapy, July 2017
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Title
Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model
Published in
Stem Cell Research & Therapy, July 2017
DOI 10.1186/s13287-017-0603-5
Pubmed ID
Authors

An Martens, Sofie Ordies, Bart M. Vanaudenaerde, Stijn E. Verleden, Robin Vos, Dirk E. Van Raemdonck, Geert M. Verleden, Valerie D. Roobrouck, Sandra Claes, Dominique Schols, Eric Verbeken, Catherine M. Verfaillie, Arne P. Neyrinck

Abstract

Primary graft dysfunction (PGD) is considered to be the end result of an inflammatory response targeting the new lung allograft after transplant. Previous research has indicated that MAPC cell therapy might attenuate this injury by its paracrine effects on the pro-/anti-inflammatory balance. This study aims to investigate the immunoregulatory capacities of MAPC cells in PGD when administered in the airways. Lungs of domestic pigs (n = 6/group) were subjected to 90 minutes of warm ischemia. Lungs were cold flushed, cannulated on ice and placed on EVLP for 6 hours. At the start of EVLP, 40 ml of an albumin-plasmalyte mixture was distributed in the airways (CONTR group). In the MAPC cell group, 150 million MAPC cells (ReGenesys/Athersys, Cleveland, OH, USA) were added to this mixture. At the end of EVLP, a physiological evaluation (pulmonary vascular resistance, lung compliance, PaO2/FiO2), wet-to-dry weight ratio (W/D) sampling and a multiplex analysis of bronchoalveolar lavage (BAL) (2 × 30 ml) was performed. Pulmonary vascular resistance, lung compliance, PaO2/FiO2 and W/D were not statistically different at the end of EVLP between both groups. BAL neutrophilia was significantly reduced in the MAPC cell group. Moreover, there was a significant decrease in TNF-α, IL-1β and IFN-γ in the BAL, but not in IFN-α; whereas IL-4, IL-10 and IL-8 were below the detection limit. Although no physiologic effect of MAPC cell distribution in the airways was detected during EVLP, we observed a reduction in pro-inflammatory cytokines and neutrophils in BAL in the MAPC cell group. This effect on the innate immune system might play an important role in critically modifying the process of PGD after transplantation. Further experiments will have to elucidate the immunoregulatory effect of MAPC cell administration on graft function after transplantation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 17%
Student > Bachelor 7 13%
Researcher 5 10%
Student > Ph. D. Student 5 10%
Other 4 8%
Other 12 23%
Unknown 10 19%
Readers by discipline Count As %
Medicine and Dentistry 21 40%
Biochemistry, Genetics and Molecular Biology 5 10%
Immunology and Microbiology 4 8%
Arts and Humanities 2 4%
Agricultural and Biological Sciences 2 4%
Other 8 15%
Unknown 10 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2018.
All research outputs
#13,325,015
of 22,985,065 outputs
Outputs from Stem Cell Research & Therapy
#920
of 2,429 outputs
Outputs of similar age
#154,532
of 313,319 outputs
Outputs of similar age from Stem Cell Research & Therapy
#31
of 65 outputs
Altmetric has tracked 22,985,065 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,429 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,319 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.