Title |
A short-term treatment with tumor necrosis factor-alpha enhances stem cell phenotype of human dental pulp cells
|
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Published in |
Stem Cell Research & Therapy, February 2014
|
DOI | 10.1186/scrt420 |
Pubmed ID | |
Authors |
Mayu Ueda, Takuo Fujisawa, Mitsuaki Ono, Emilio Satoshi Hara, Hai Thanh Pham, Ryu Nakajima, Wataru Sonoyama, Takuo Kuboki |
Abstract |
During normal pulp tissue healing, inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) or interleukins, act in the initial 48 h (inflammatory phase) and play important roles not only as chemo-attractants of inflammatory cells and stem/progenitor cells, but also in inducing a cascade of reactions toward tissue regeneration and/or reparative dentin formation. Previous reports have shown that inflammatory cytokines regulate the differentiation capacity of dental pulp stem/progenitor cells (DPCs), but none has interrogated the impact of these cytokines on the stem cell phenotype of stem/progenitor cells. This study investigated the effects of a short-term treatment with TNF-alpha on the stem cell phenotype and differentiation ability of human DPCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
India | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 16% |
Student > Bachelor | 9 | 14% |
Student > Ph. D. Student | 9 | 14% |
Student > Doctoral Student | 7 | 11% |
Student > Master | 6 | 9% |
Other | 8 | 13% |
Unknown | 15 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 39% |
Agricultural and Biological Sciences | 9 | 14% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Nursing and Health Professions | 1 | 2% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 5 | 8% |
Unknown | 19 | 30% |