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Inflammatory cascades mediate synapse elimination in spinal cord compression

Overview of attention for article published in Journal of Neuroinflammation, March 2014
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Title
Inflammatory cascades mediate synapse elimination in spinal cord compression
Published in
Journal of Neuroinflammation, March 2014
DOI 10.1186/1742-2094-11-40
Pubmed ID
Authors

Morito Takano, Soya Kawabata, Yuji Komaki, Shinsuke Shibata, Keigo Hikishima, Yoshiaki Toyama, Hideyuki Okano, Masaya Nakamura

Abstract

Cervical compressive myelopathy (CCM) is caused by chronic spinal cord compression due to spondylosis, a degenerative disc disease, and ossification of the ligaments. Tip-toe walking Yoshimura (twy) mice are reported to be an ideal animal model for CCM-related neuronal dysfunction, because they develop spontaneous spinal cord compression without any artificial manipulation. Previous histological studies showed that neurons are lost due to apoptosis in CCM, but the mechanism underlying this neurodegeneration was not fully elucidated. The purpose of this study was to investigate the pathophysiology of CCM by evaluating the global gene expression of the compressed spinal cord and comparing the transcriptome analysis with the physical and histological findings in twy mice.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 62 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 20%
Student > Bachelor 9 14%
Student > Ph. D. Student 9 14%
Student > Master 6 9%
Other 5 8%
Other 12 19%
Unknown 10 16%
Readers by discipline Count As %
Medicine and Dentistry 22 34%
Neuroscience 8 13%
Agricultural and Biological Sciences 7 11%
Nursing and Health Professions 3 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 8 13%
Unknown 14 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2014.
All research outputs
#18,366,246
of 22,747,498 outputs
Outputs from Journal of Neuroinflammation
#2,058
of 2,617 outputs
Outputs of similar age
#160,893
of 221,286 outputs
Outputs of similar age from Journal of Neuroinflammation
#28
of 41 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,617 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,286 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.