Title |
Inflammatory cascades mediate synapse elimination in spinal cord compression
|
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Published in |
Journal of Neuroinflammation, March 2014
|
DOI | 10.1186/1742-2094-11-40 |
Pubmed ID | |
Authors |
Morito Takano, Soya Kawabata, Yuji Komaki, Shinsuke Shibata, Keigo Hikishima, Yoshiaki Toyama, Hideyuki Okano, Masaya Nakamura |
Abstract |
Cervical compressive myelopathy (CCM) is caused by chronic spinal cord compression due to spondylosis, a degenerative disc disease, and ossification of the ligaments. Tip-toe walking Yoshimura (twy) mice are reported to be an ideal animal model for CCM-related neuronal dysfunction, because they develop spontaneous spinal cord compression without any artificial manipulation. Previous histological studies showed that neurons are lost due to apoptosis in CCM, but the mechanism underlying this neurodegeneration was not fully elucidated. The purpose of this study was to investigate the pathophysiology of CCM by evaluating the global gene expression of the compressed spinal cord and comparing the transcriptome analysis with the physical and histological findings in twy mice. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
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Researcher | 13 | 20% |
Student > Bachelor | 9 | 14% |
Student > Ph. D. Student | 9 | 14% |
Student > Master | 6 | 9% |
Other | 5 | 8% |
Other | 12 | 19% |
Unknown | 10 | 16% |
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Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 8 | 13% |
Unknown | 14 | 22% |