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Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer

Overview of attention for article published in Diagnostic Pathology, March 2014
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1 X user

Citations

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Title
Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer
Published in
Diagnostic Pathology, March 2014
DOI 10.1186/1746-1596-9-48
Pubmed ID
Authors

Angela Fuchs, Katharina König, Lukas C Heukamp, Jana Fassunke, Jutta Kirfel, Sebastian Huss, Albert J Becker, Reinhard Büttner, Michael Majores

Abstract

Hamartin (TSC1) and tuberin (TSC2), encoded by the tuberous sclerosis complex (TSC) genes, form a tumor-suppressor heterodimer which is implicated in PI3K-Akt signaling and acts as a functional inhibitor of the mammalian target of rapamycin (mTOR). Dysregulation of mTOR has been assigned to carcinogenesis and thus may be involved in cancer development. We have addressed the role of hamartin, phospho-tuberin (p-TSC2) and phospho-mTOR (p-mTOR) in a series of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) samples.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 25%
Student > Bachelor 5 18%
Student > Master 5 18%
Student > Ph. D. Student 2 7%
Lecturer 1 4%
Other 3 11%
Unknown 5 18%
Readers by discipline Count As %
Medicine and Dentistry 8 29%
Biochemistry, Genetics and Molecular Biology 7 25%
Agricultural and Biological Sciences 4 14%
Computer Science 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 0 0%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2014.
All research outputs
#18,366,246
of 22,747,498 outputs
Outputs from Diagnostic Pathology
#758
of 1,122 outputs
Outputs of similar age
#160,893
of 221,286 outputs
Outputs of similar age from Diagnostic Pathology
#32
of 52 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,122 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,286 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.