Title |
Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile
|
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Published in |
Journal of Translational Medicine, March 2014
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DOI | 10.1186/1479-5876-12-59 |
Pubmed ID | |
Authors |
Raphael Lis, Cyril Touboul, Najeeb M Halabi, Abishek Sainath Madduri, Denis Querleu, Jason Mezey, Joel A Malek, Karsten Suhre, Arash Rafii |
Abstract |
The cross talk between the stroma and cancer cells plays a major role in phenotypic modulation. During peritoneal carcinomatosis ovarian cancer cells interact with mesenchymal stem cells (MSC) resulting in increased metastatic ability. Understanding the transcriptomic changes underlying the phenotypic modulation will allow identification of key genes to target. However in the context of personalized medicine we must consider inter and intra tumoral heterogeneity. In this study we used a pathway-based approach to illustrate the role of cell line background in transcriptomic modification during a cross talk with MSC. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
India | 1 | 2% |
Uruguay | 1 | 2% |
Unknown | 54 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 28% |
Student > Master | 10 | 18% |
Researcher | 7 | 12% |
Professor | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 8 | 14% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 15 | 26% |
Agricultural and Biological Sciences | 12 | 21% |
Medicine and Dentistry | 9 | 16% |
Nursing and Health Professions | 3 | 5% |
Neuroscience | 2 | 4% |
Other | 6 | 11% |
Unknown | 10 | 18% |