Title |
Imaging of carotid artery vessel wall edema using T2-weighted cardiovascular magnetic resonance
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Published in |
Critical Reviews in Diagnostic Imaging, March 2014
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DOI | 10.1186/1532-429x-16-22 |
Pubmed ID | |
Authors |
Lars Ølgaard Bloch, Anne Yoon Krogh Grøndal Hansen, Steen Fjord Pedersen, Jesper Langhoff Honge, Won Yong Kim, Esben Søvsø Szocska Hansen |
Abstract |
Atherothrombosis remains a major health problem in the western world, and carotid atherosclerosis is an important contributor to embolic ischemic strokes. It remains a clinical challenge to identify rupture-prone atherosclerotic plaques before clinical events occur. Inflammation, endothelial injury and angiogenesis are features of vulnerable plaques and may all be associated with plaque edema. Therefore, vessel wall edema, which can be detected by 2D T2-weighted cardiovascular magnetic resonance (CMR), may be used as a dynamic marker of disease activity in the atherosclerotic plaque. However, 2D imaging is limited by low spatial resolution in the slice-select direction compared to 3D imaging techniques. We sought to investigate the ability of novel 3D techniques to detect edema induced in porcine carotid arteries by acute balloon injury compared to conventional 2D T2-weighted black-blood CMR. |
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