Title |
Bacterial group I introns: mobile RNA catalysts
|
---|---|
Published in |
Mobile DNA, March 2014
|
DOI | 10.1186/1759-8753-5-8 |
Pubmed ID | |
Authors |
Georg Hausner, Mohamed Hafez, David R Edgell |
Abstract |
Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by acting as ribozymes, potentially renders their insertion into genes phenotypically neutral. Some group I introns are mobile genetic elements due to encoded homing endonuclease genes that function in DNA-based mobility pathways to promote spread to intronless alleles. Group I introns have a limited distribution among bacteria and the current assumption is that they are benign selfish elements, although some introns and homing endonucleases are a source of genetic novelty as they have been co-opted by host genomes to provide regulatory functions. Questions regarding the origin and maintenance of group I introns among the bacteria and phages are also addressed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Germany | 1 | <1% |
Unknown | 131 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 19% |
Researcher | 20 | 15% |
Student > Bachelor | 18 | 13% |
Student > Master | 17 | 13% |
Professor | 8 | 6% |
Other | 19 | 14% |
Unknown | 26 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 47 | 35% |
Agricultural and Biological Sciences | 41 | 31% |
Computer Science | 3 | 2% |
Chemistry | 3 | 2% |
Business, Management and Accounting | 2 | 1% |
Other | 7 | 5% |
Unknown | 31 | 23% |