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The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency

Overview of attention for article published in BMC Medical Genomics, March 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
2 blogs
wikipedia
8 Wikipedia pages

Citations

dimensions_citation
137 Dimensions

Readers on

mendeley
73 Mendeley
citeulike
1 CiteULike
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Title
The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency
Published in
BMC Medical Genomics, March 2008
DOI 10.1186/1471-2350-9-20
Pubmed ID
Authors

Jean-Pierre Bayley, Virpi Launonen, Ian PM Tomlinson

Abstract

Fumarate hydratase (HGNC approved gene symbol - FH), also known as fumarase, is an enzyme of the tricarboxylic acid (TCA) cycle, involved in fundamental cellular energy production. First described by Zinn et al in 1986, deficiency of FH results in early onset, severe encephalopathy. In 2002, the Multiple Leiomyoma Consortium identified heterozygous germline mutations of FH in patients with multiple cutaneous and uterine leiomyomas, (MCUL: OMIM 150800). In some families renal cell cancer also forms a component of the complex and as such has been described as hereditary leiomyomatosis and renal cell cancer (HLRCC: OMIM 605839). The identification of FH as a tumor suppressor was an unexpected finding and following the identification of subunits of succinate dehydrogenase in 2000 and 2001, was only the second description of the involvement of an enzyme of intermediary metabolism in tumorigenesis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 19%
Other 10 14%
Student > Ph. D. Student 10 14%
Student > Bachelor 6 8%
Professor > Associate Professor 6 8%
Other 12 16%
Unknown 15 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 23%
Biochemistry, Genetics and Molecular Biology 15 21%
Medicine and Dentistry 13 18%
Chemistry 2 3%
Nursing and Health Professions 1 1%
Other 5 7%
Unknown 20 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2023.
All research outputs
#2,657,552
of 25,394,764 outputs
Outputs from BMC Medical Genomics
#125
of 2,444 outputs
Outputs of similar age
#7,494
of 95,738 outputs
Outputs of similar age from BMC Medical Genomics
#1
of 11 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,444 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,738 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.