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Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA

Overview of attention for article published in Acta Neuropathologica Communications, March 2014
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92 Mendeley
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1 CiteULike
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Title
Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA
Published in
Acta Neuropathologica Communications, March 2014
DOI 10.1186/2051-5960-2-29
Pubmed ID
Authors

Dominique Bétemps, Jérémy Verchère, Sébastien Brot, Eric Morignat, Luc Bousset, Damien Gaillard, Latifa Lakhdar, Ronald Melki, Thierry Baron

Abstract

The accumulation of misfolded proteins appears as a fundamental pathogenic process in human neurodegenerative diseases. In the case of synucleinopathies such as Parkinson's disease (PD) or dementia with Lewy bodies (DLB), the intraneuronal deposition of aggregated alpha-synuclein (αS) is a major characteristic of the disease, but the molecular basis distinguishing the disease-associated protein (αSD) from its normal counterpart remains poorly understood. However, recent research suggests that a prion-like mechanism could be involved in the inter-cellular and inter-molecular propagation of aggregation of the protein within the nervous system.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 91 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 21%
Student > Ph. D. Student 16 17%
Student > Master 11 12%
Student > Bachelor 9 10%
Professor > Associate Professor 6 7%
Other 17 18%
Unknown 14 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 22%
Neuroscience 18 20%
Biochemistry, Genetics and Molecular Biology 14 15%
Medicine and Dentistry 8 9%
Engineering 4 4%
Other 12 13%
Unknown 16 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2014.
All research outputs
#14,191,572
of 22,747,498 outputs
Outputs from Acta Neuropathologica Communications
#1,070
of 1,369 outputs
Outputs of similar age
#117,809
of 221,235 outputs
Outputs of similar age from Acta Neuropathologica Communications
#14
of 30 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,235 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.