Title |
Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA
|
---|---|
Published in |
Acta Neuropathologica Communications, March 2014
|
DOI | 10.1186/2051-5960-2-29 |
Pubmed ID | |
Authors |
Dominique Bétemps, Jérémy Verchère, Sébastien Brot, Eric Morignat, Luc Bousset, Damien Gaillard, Latifa Lakhdar, Ronald Melki, Thierry Baron |
Abstract |
The accumulation of misfolded proteins appears as a fundamental pathogenic process in human neurodegenerative diseases. In the case of synucleinopathies such as Parkinson's disease (PD) or dementia with Lewy bodies (DLB), the intraneuronal deposition of aggregated alpha-synuclein (αS) is a major characteristic of the disease, but the molecular basis distinguishing the disease-associated protein (αSD) from its normal counterpart remains poorly understood. However, recent research suggests that a prion-like mechanism could be involved in the inter-cellular and inter-molecular propagation of aggregation of the protein within the nervous system. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 91 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 21% |
Student > Ph. D. Student | 16 | 17% |
Student > Master | 11 | 12% |
Student > Bachelor | 9 | 10% |
Professor > Associate Professor | 6 | 7% |
Other | 17 | 18% |
Unknown | 14 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 22% |
Neuroscience | 18 | 20% |
Biochemistry, Genetics and Molecular Biology | 14 | 15% |
Medicine and Dentistry | 8 | 9% |
Engineering | 4 | 4% |
Other | 12 | 13% |
Unknown | 16 | 17% |