Title |
Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease
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Published in |
BMC Genomics, March 2014
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DOI | 10.1186/1471-2164-15-199 |
Pubmed ID | |
Authors |
Puneet Talwar, Yumnam Silla, Sandeep Grover, Meenal Gupta, Rachna Agarwal, Suman Kushwaha, Ritushree Kukreti |
Abstract |
Alzheimer's disease (AD) is one of the leading genetically complex and heterogeneous disorder that is influenced by both genetic and environmental factors. The underlying risk factors remain largely unclear for this heterogeneous disorder. In recent years, high throughput methodologies, such as genome-wide linkage analysis (GWL), genome-wide association (GWA) studies, and genome-wide expression profiling (GWE), have led to the identification of several candidate genes associated with AD. However, due to lack of consistency within their findings, an integrative approach is warranted. Here, we have designed a rank based gene prioritization approach involving convergent analysis of multi-dimensional data and protein-protein interaction (PPI) network modelling. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 27% |
United States | 2 | 18% |
Switzerland | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 73% |
Scientists | 2 | 18% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | <1% |
Sweden | 1 | <1% |
Unknown | 126 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 25% |
Researcher | 18 | 14% |
Student > Master | 16 | 13% |
Student > Bachelor | 13 | 10% |
Professor > Associate Professor | 6 | 5% |
Other | 18 | 14% |
Unknown | 25 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 24% |
Biochemistry, Genetics and Molecular Biology | 21 | 16% |
Medicine and Dentistry | 15 | 12% |
Computer Science | 9 | 7% |
Neuroscience | 8 | 6% |
Other | 13 | 10% |
Unknown | 31 | 24% |