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Bistability and hysteresis of the 'Secteur' differentiation are controlled by a two-gene locus in Nectria haematococca

Overview of attention for article published in BMC Biology, August 2004
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Title
Bistability and hysteresis of the 'Secteur' differentiation are controlled by a two-gene locus in Nectria haematococca
Published in
BMC Biology, August 2004
DOI 10.1186/1741-7007-2-18
Pubmed ID
Authors

Stéphane Graziani, Philippe Silar, Marie-Josée Daboussi

Abstract

Bistability and hysteresis are increasingly recognized as major properties of regulatory networks governing numerous biological phenomena, such as differentiation and cell cycle progression. The full scope of the underlying molecular mechanisms leading to bistability and hysteresis remains elusive. Nectria haemaotcocca, a saprophytic or pathogenic fungus with sexual reproduction, exhibits a bistable morphological modification characterized by a reduced growth rate and an intense pigmentation. Bistability is triggered by the presence or absence of sigma, a cytoplasmic determinant. This determinant spreads in an infectious manner in the hyphae of the growing margin, insuring hysteresis of the differentiation.

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 29%
Other 3 18%
Student > Doctoral Student 2 12%
Student > Bachelor 2 12%
Researcher 2 12%
Other 3 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 59%
Engineering 2 12%
Biochemistry, Genetics and Molecular Biology 2 12%
Environmental Science 1 6%
Chemistry 1 6%
Other 1 6%