Title |
Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model
|
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Published in |
The Journal of Headache and Pain, March 2014
|
DOI | 10.1186/1129-2377-15-14 |
Pubmed ID | |
Authors |
Rosaria Greco, Antonina Stefania Mangione, Giorgio Sandrini, Giuseppe Nappi, Cristina Tassorelli |
Abstract |
Experimental animal models of migraine have suggested the existence of interactions between the endocannabinoid system and pain mediation in migraine. Extensive evidence has demonstrated a role for the cannabinoid-1 (CB1) receptor in antinociception. However, recent research suggests that also CB2 receptors, especially located outside the central nervous system, play a role in the perception of pain. Systemic administration of nitroglycerin (NTG) consistently induces spontaneous-like headache attacks in migraneurs; in the rat, systemic NTG induces a condition of hyperalgesia, probably through the activation of cerebral/spinal structures involved in nociceptive transmission. In this study we evaluated the role of CB2 receptors in two animal models of pain that may be relevant for migraine: the tail flick test and the formalin test performed during NTG-induced hyperalgesia. |
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