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Is atherosclerosis an autoimmune disease?

Overview of attention for article published in BMC Medicine, March 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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28 X users
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5 Facebook pages

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126 Dimensions

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127 Mendeley
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Title
Is atherosclerosis an autoimmune disease?
Published in
BMC Medicine, March 2014
DOI 10.1186/1741-7015-12-47
Pubmed ID
Authors

Eiji Matsuura, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Maurizio Turiel, Luis R Lopez, Michael T Nurmohamed

Abstract

Immunologic research into pathogenic mechanisms operating in autoimmune-mediated atherosclerosis initially focused on adaptive immunity. Current interest is directed to more basic inflammatory mechanisms. Chronic inflammation (innate immunity-associated) may trigger initial events that can lead to atherosclerotic cardiovascular disease. This chronic inflammation may start early in life and be perpetuated by classic atherosclerosis risk factors. Lipid peroxidation of low-density lipoprotein seems to be a key event in the initiation and progression of atherosclerosis. Oxidized low-density lipoprotein triggers inflammatory and immunogenic events that promote endothelial dysfunction and the synthesis and secretion of pro-inflammatory cytokines, leading to an autoimmune response capable of accelerating the intracellular accumulation of lipids within atherosclerotic plaques. Oxidized low-density lipoprotein binds β2-glycoprotein I to form circulating complexes found in both autoimmune and non-autoimmune atherosclerosis. It is likely that β2-glycoprotein I and/or these complexes contribute to early atherogenesis by stimulating pro-inflammatory innate immunity through endogenous sensors and inflammasome/interleukin-1 pathways. We discuss the chronic inflammatory (innate) and autoimmune (adaptive) responses operating in atherosclerosis to discern the role of autoimmunity in atherosclerotic cardiovascular disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Indonesia 1 <1%
Brazil 1 <1%
India 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 121 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 20%
Student > Bachelor 21 17%
Student > Ph. D. Student 17 13%
Student > Doctoral Student 12 9%
Student > Master 11 9%
Other 20 16%
Unknown 20 16%
Readers by discipline Count As %
Medicine and Dentistry 41 32%
Agricultural and Biological Sciences 17 13%
Biochemistry, Genetics and Molecular Biology 13 10%
Immunology and Microbiology 10 8%
Pharmacology, Toxicology and Pharmaceutical Science 6 5%
Other 12 9%
Unknown 28 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2020.
All research outputs
#1,732,552
of 22,749,166 outputs
Outputs from BMC Medicine
#1,200
of 3,413 outputs
Outputs of similar age
#20,307
of 242,903 outputs
Outputs of similar age from BMC Medicine
#20
of 55 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,413 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,903 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.