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Bone metabolism and inflammatory characteristics in 14 cases of chronic nonbacterial osteomyelitis

Overview of attention for article published in Pediatric Rheumatology, July 2017
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2 tweeters
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1 Facebook page

Citations

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6 Dimensions

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51 Mendeley
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Title
Bone metabolism and inflammatory characteristics in 14 cases of chronic nonbacterial osteomyelitis
Published in
Pediatric Rheumatology, July 2017
DOI 10.1186/s12969-017-0183-z
Pubmed ID
Authors

Yurika Ata, Yutaka Inaba, Hyonmin Choe, Naomi Kobayashi, Jiro Machida, Naoyuki Nakamura, Tomoyuki Saito

Abstract

Chronic nonbacterial osteomyelitis (CNO) is a multifocal autoinflammatory disease that often impairs daily life in children. This study aimed to investigate the bone metabolic and inflammatory characteristics of patients with CNO, and to assess the differences between responders and nonresponders to conservative treatment. We investigated the clinical symptoms; laboratory data including inflammatory and bone metabolic biomarkers; and imaging findings from plain radiography, magnetic resonance imaging (MRI), fluorodeoxyglucose-positron emission tomography (FDG-PET), and dual-energy x-ray absorption (DEXA) in 14 patients with CNO. All patients underwent first-line treatment comprising systemic nonsteroidal anti-inflammatory drugs with or without bisphosphonate. According to the response to the first-line treatment, the patients were divided into the clinical remission/partial response group and the no response group. The differences in bone metabolic and inflammatory characteristics between the two groups were assessed. All patients had low bone mineral density assessed with DEXA. The bone metabolic biomarkers (bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase 5b) were increased in boys of all ages and in young girls. Multiple inflammatory regions were detected in all patients by using FDG-PET including asymptomatic regions. The no response group had higher immunoglobulin G (IgG) and a greater number of bone inflammatory lesions detected on MRI than the clinical remission/partial response group. Our data indicate the involvement of abnormal bone turnover, necessity of whole-body scanning, and association of higher serum IgG levels and greater numbers of inflammatory lesions with prolonged disease activity in patients with CNO.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Other 7 14%
Researcher 5 10%
Student > Master 5 10%
Student > Postgraduate 3 6%
Other 8 16%
Unknown 14 27%
Readers by discipline Count As %
Medicine and Dentistry 23 45%
Biochemistry, Genetics and Molecular Biology 4 8%
Immunology and Microbiology 2 4%
Nursing and Health Professions 1 2%
Psychology 1 2%
Other 3 6%
Unknown 17 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2019.
All research outputs
#9,756,699
of 15,335,820 outputs
Outputs from Pediatric Rheumatology
#297
of 458 outputs
Outputs of similar age
#126,641
of 216,588 outputs
Outputs of similar age from Pediatric Rheumatology
#1
of 1 outputs
Altmetric has tracked 15,335,820 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 458 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 216,588 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them