Title |
Leucine modulates dynamic phosphorylation events in insulin signaling pathway and enhances insulin-dependent glycogen synthesis in human skeletal muscle cells
|
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Published in |
BMC Molecular and Cell Biology, March 2014
|
DOI | 10.1186/1471-2121-15-9 |
Pubmed ID | |
Authors |
Barbara Di Camillo, Federica Eduati, Sreekumaran K Nair, Angelo Avogaro, Gianna M Toffolo |
Abstract |
Branched-chain amino acids, especially leucine, are known to interact with insulin signaling pathway and glucose metabolism. However, the mechanism by which this is exerted, remain to be clearly defined. In order to examine the effect of leucine on muscle insulin signaling, a set of experiments was carried out to quantitate phosphorylation events along the insulin signaling pathway in human skeletal muscle cell cultures. Cells were exposed to insulin, leucine or both, and phosphorylation events of key insulin signaling molecules were tracked over time so as to monitor time-related responses that characterize the signaling events and could be missed by a single sampling strategy limited to pre/post stimulus events. |
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