Title |
A statistical framework for differential network analysis from microarray data
|
---|---|
Published in |
BMC Bioinformatics, February 2010
|
DOI | 10.1186/1471-2105-11-95 |
Pubmed ID | |
Authors |
Ryan Gill, Somnath Datta, Susmita Datta |
Abstract |
It has been long well known that genes do not act alone; rather groups of genes act in consort during a biological process. Consequently, the expression levels of genes are dependent on each other. Experimental techniques to detect such interacting pairs of genes have been in place for quite some time. With the advent of microarray technology, newer computational techniques to detect such interaction or association between gene expressions are being proposed which lead to an association network. While most microarray analyses look for genes that are differentially expressed, it is of potentially greater significance to identify how entire association network structures change between two or more biological settings, say normal versus diseased cell types. |
Mendeley readers
Geographical breakdown
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Sweden | 2 | 1% |
Luxembourg | 2 | 1% |
Canada | 2 | 1% |
South Africa | 1 | <1% |
Finland | 1 | <1% |
Brazil | 1 | <1% |
France | 1 | <1% |
Other | 7 | 4% |
Unknown | 159 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 49 | 27% |
Researcher | 42 | 23% |
Professor > Associate Professor | 18 | 10% |
Student > Master | 15 | 8% |
Professor | 11 | 6% |
Other | 33 | 18% |
Unknown | 14 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 72 | 40% |
Biochemistry, Genetics and Molecular Biology | 22 | 12% |
Computer Science | 21 | 12% |
Mathematics | 17 | 9% |
Engineering | 10 | 5% |
Other | 25 | 14% |
Unknown | 15 | 8% |