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LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

Overview of attention for article published in Journal of Neuroinflammation, January 2014
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Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
132 Dimensions

Readers on

mendeley
189 Mendeley
citeulike
3 CiteULike
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Title
LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
Published in
Journal of Neuroinflammation, January 2014
DOI 10.1186/1742-2094-11-52
Pubmed ID
Authors

Isabella Russo, Luigi Bubacco, Elisa Greggio

Abstract

It is now well established that chronic inflammation is a prominent feature of several neurodegenerative disorders including Parkinson's disease (PD). Growing evidence indicates that neuroinflammation can contribute greatly to dopaminergic neuron degeneration and progression of the disease. Recent literature highlights that leucine-rich repeat kinase 2 (LRRK2), a kinase mutated in both autosomal-dominantly inherited and sporadic PD cases, modulates inflammation in response to different pathological stimuli. In this review, we outline the state of the art of LRRK2 functions in microglia cells and in neuroinflammation. Furthermore, we discuss the potential role of LRRK2 in cytoskeleton remodeling and vesicle trafficking in microglia cells under physiological and pathological conditions. We also hypothesize that LRRK2 mutations might sensitize microglia cells toward a pro-inflammatory state, which in turn results in exacerbated inflammation with consequent neurodegeneration.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 189 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
United Kingdom 2 1%
Italy 1 <1%
Portugal 1 <1%
Australia 1 <1%
Unknown 182 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 24%
Student > Master 29 15%
Researcher 27 14%
Student > Bachelor 27 14%
Student > Doctoral Student 11 6%
Other 26 14%
Unknown 24 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 46 24%
Neuroscience 46 24%
Biochemistry, Genetics and Molecular Biology 23 12%
Medicine and Dentistry 21 11%
Pharmacology, Toxicology and Pharmaceutical Science 6 3%
Other 21 11%
Unknown 26 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2016.
All research outputs
#12,703,104
of 22,749,166 outputs
Outputs from Journal of Neuroinflammation
#1,330
of 2,617 outputs
Outputs of similar age
#154,554
of 305,230 outputs
Outputs of similar age from Journal of Neuroinflammation
#29
of 55 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,617 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,230 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.