Title |
LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
|
---|---|
Published in |
Journal of Neuroinflammation, March 2014
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DOI | 10.1186/1742-2094-11-52 |
Pubmed ID | |
Authors |
Isabella Russo, Luigi Bubacco, Elisa Greggio |
Abstract |
It is now well established that chronic inflammation is a prominent feature of several neurodegenerative disorders including Parkinson's disease (PD). Growing evidence indicates that neuroinflammation can contribute greatly to dopaminergic neuron degeneration and progression of the disease. Recent literature highlights that leucine-rich repeat kinase 2 (LRRK2), a kinase mutated in both autosomal-dominantly inherited and sporadic PD cases, modulates inflammation in response to different pathological stimuli. In this review, we outline the state of the art of LRRK2 functions in microglia cells and in neuroinflammation. Furthermore, we discuss the potential role of LRRK2 in cytoskeleton remodeling and vesicle trafficking in microglia cells under physiological and pathological conditions. We also hypothesize that LRRK2 mutations might sensitize microglia cells toward a pro-inflammatory state, which in turn results in exacerbated inflammation with consequent neurodegeneration. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 20% |
United Kingdom | 1 | 20% |
Australia | 1 | 20% |
United States | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
United Kingdom | 2 | 1% |
Italy | 1 | <1% |
Portugal | 1 | <1% |
Australia | 1 | <1% |
Unknown | 192 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 45 | 23% |
Student > Master | 30 | 15% |
Student > Bachelor | 27 | 14% |
Researcher | 26 | 13% |
Student > Doctoral Student | 13 | 7% |
Other | 28 | 14% |
Unknown | 30 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 47 | 24% |
Agricultural and Biological Sciences | 46 | 23% |
Biochemistry, Genetics and Molecular Biology | 25 | 13% |
Medicine and Dentistry | 21 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 21 | 11% |
Unknown | 33 | 17% |