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LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

Overview of attention for article published in Journal of Neuroinflammation, March 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

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5 X users

Citations

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147 Dimensions

Readers on

mendeley
199 Mendeley
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3 CiteULike
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Title
LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
Published in
Journal of Neuroinflammation, March 2014
DOI 10.1186/1742-2094-11-52
Pubmed ID
Authors

Isabella Russo, Luigi Bubacco, Elisa Greggio

Abstract

It is now well established that chronic inflammation is a prominent feature of several neurodegenerative disorders including Parkinson's disease (PD). Growing evidence indicates that neuroinflammation can contribute greatly to dopaminergic neuron degeneration and progression of the disease. Recent literature highlights that leucine-rich repeat kinase 2 (LRRK2), a kinase mutated in both autosomal-dominantly inherited and sporadic PD cases, modulates inflammation in response to different pathological stimuli. In this review, we outline the state of the art of LRRK2 functions in microglia cells and in neuroinflammation. Furthermore, we discuss the potential role of LRRK2 in cytoskeleton remodeling and vesicle trafficking in microglia cells under physiological and pathological conditions. We also hypothesize that LRRK2 mutations might sensitize microglia cells toward a pro-inflammatory state, which in turn results in exacerbated inflammation with consequent neurodegeneration.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
United Kingdom 2 1%
Italy 1 <1%
Portugal 1 <1%
Australia 1 <1%
Unknown 192 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 23%
Student > Master 30 15%
Student > Bachelor 27 14%
Researcher 26 13%
Student > Doctoral Student 13 7%
Other 28 14%
Unknown 30 15%
Readers by discipline Count As %
Neuroscience 47 24%
Agricultural and Biological Sciences 46 23%
Biochemistry, Genetics and Molecular Biology 25 13%
Medicine and Dentistry 21 11%
Pharmacology, Toxicology and Pharmaceutical Science 6 3%
Other 21 11%
Unknown 33 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2016.
All research outputs
#14,387,227
of 25,371,288 outputs
Outputs from Journal of Neuroinflammation
#1,541
of 2,951 outputs
Outputs of similar age
#112,963
of 237,283 outputs
Outputs of similar age from Journal of Neuroinflammation
#16
of 45 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,283 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.