Title |
Electrochemotherapy: from the drawing board into medical practice
|
---|---|
Published in |
BioMedical Engineering OnLine, March 2014
|
DOI | 10.1186/1475-925x-13-29 |
Pubmed ID | |
Authors |
Damijan Miklavčič, Barbara Mali, Bor Kos, Richard Heller, Gregor Serša |
Abstract |
Electrochemotherapy is a local treatment of cancer employing electric pulses to improve transmembrane transfer of cytotoxic drugs. In this paper we discuss electrochemotherapy from the perspective of biomedical engineering and review the steps needed to move such a treatment from initial prototypes into clinical practice. In the paper also basic theory of electrochemotherapy and preclinical studies in vitro and in vivo are briefly reviewed. Following this we present a short review of recent clinical publications and discuss implementation of electrochemotherapy into standard of care for treatment of skin tumors, and use of electrochemotherapy for other targets such as head and neck cancer, deep-seated tumors in the liver and intestinal tract, and brain metastases. Electrodes used in these specific cases are presented with their typical voltage amplitudes used in electrochemotherapy. Finally, key points on what should be investigated in the future are presented and discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Denmark | 1 | <1% |
Italy | 1 | <1% |
Germany | 1 | <1% |
Unknown | 248 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 55 | 22% |
Researcher | 36 | 14% |
Student > Master | 30 | 12% |
Student > Bachelor | 30 | 12% |
Student > Doctoral Student | 18 | 7% |
Other | 30 | 12% |
Unknown | 53 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 47 | 19% |
Medicine and Dentistry | 43 | 17% |
Biochemistry, Genetics and Molecular Biology | 35 | 14% |
Veterinary Science and Veterinary Medicine | 15 | 6% |
Agricultural and Biological Sciences | 13 | 5% |
Other | 35 | 14% |
Unknown | 64 | 25% |