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Elevated malondialdehyde levels in sepsis - something to 'stress' about?

Overview of attention for article published in Critical Care, March 2014
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Title
Elevated malondialdehyde levels in sepsis - something to 'stress' about?
Published in
Critical Care, March 2014
DOI 10.1186/cc13786
Pubmed ID
Authors

Scott L Weiss, Clifford S Deutschman

Abstract

Oxidative stress has been postulated as a mechanism of organ dysfunction - and thus a potential therapeutic target - in sepsis. Lorente and colleagues report increased serum levels of malondialdehyde, a biomarker of oxidative stress-induced lipid peroxidation, in adults with severe sepsis, particularly in non-survivors. While survivors exhibited a decrease in serum malondialdehyde over time, the elevation was sustained in non-survivors. These findings suggest that there is increased oxidative stress in sepsis and that membrane lipids in particular are targeted by free radical species. Further study is required to validate the utility of malondialdehyde as a prognostic biomarker in sepsis and to determine a role for antioxidant therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 19%
Student > Master 5 10%
Researcher 4 8%
Lecturer 4 8%
Other 2 4%
Other 8 17%
Unknown 16 33%
Readers by discipline Count As %
Medicine and Dentistry 12 25%
Chemistry 4 8%
Agricultural and Biological Sciences 4 8%
Nursing and Health Professions 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 7 15%
Unknown 17 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2020.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Critical Care
#5,468
of 6,554 outputs
Outputs of similar age
#142,535
of 236,824 outputs
Outputs of similar age from Critical Care
#111
of 150 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,824 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 150 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.