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Transcriptome analysis identifies Bacillus anthracis genes that respond to CO2through an AtxA-dependent mechanism

Overview of attention for article published in BMC Genomics, March 2014
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  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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4 X users

Citations

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39 Mendeley
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Title
Transcriptome analysis identifies Bacillus anthracis genes that respond to CO2through an AtxA-dependent mechanism
Published in
BMC Genomics, March 2014
DOI 10.1186/1471-2164-15-229
Pubmed ID
Authors

Andrew T McKenzie, Andrei P Pomerantsev, Inka Sastalla, Craig Martens, Stacy M Ricklefs, Kimmo Virtaneva, Sarah Anzick, Stephen F Porcella, Stephen H Leppla

Abstract

Upon infection of a mammalian host, Bacillus anthracis responds to host cues, and particularly to elevated temperature (37°C) and bicarbonate/CO2 concentrations, with increased expression of virulence factors that include the anthrax toxins and extracellular capsular layer. This response requires the presence of the pXO1 virulence plasmid-encoded pleiotropic regulator AtxA. To better understand the genetic basis of this response, we utilized a controlled in vitro system and Next Generation sequencing to determine and compare RNA expression profiles of the parental strain and an isogenic AtxA-deficient strain in a 2 × 2 factorial design with growth environments containing or lacking carbon dioxide.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 3%
Brazil 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 31%
Student > Ph. D. Student 7 18%
Student > Doctoral Student 5 13%
Student > Master 4 10%
Professor > Associate Professor 3 8%
Other 6 15%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 46%
Biochemistry, Genetics and Molecular Biology 8 21%
Engineering 3 8%
Immunology and Microbiology 2 5%
Computer Science 2 5%
Other 3 8%
Unknown 3 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2014.
All research outputs
#15,013,963
of 25,529,543 outputs
Outputs from BMC Genomics
#5,176
of 11,275 outputs
Outputs of similar age
#118,139
of 237,973 outputs
Outputs of similar age from BMC Genomics
#87
of 216 outputs
Altmetric has tracked 25,529,543 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,275 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,973 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 216 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.