↓ Skip to main content

Cell-matrix interactions in dermal repair and scarring

Overview of attention for article published in Fibrogenesis & Tissue Repair, March 2010
Altmetric Badge

Mentioned by

facebook
2 Facebook pages

Citations

dimensions_citation
120 Dimensions

Readers on

mendeley
205 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Cell-matrix interactions in dermal repair and scarring
Published in
Fibrogenesis & Tissue Repair, March 2010
DOI 10.1186/1755-1536-3-4
Pubmed ID
Authors

Beate Eckes, Roswitha Nischt, Thomas Krieg

Abstract

Regulation of cellular functions during dermal repair following injury is complex and critically dependent on the interaction of cells with the surrounding extracellular matrix (ECM). The ECM comprises various families of macromolecules that form the structural scaffold of the tissue, but also carry distinct biological activities. After injury to the skin, the defect is filled by a provisional matrix that is invaded by inflammatory cells, sprouting blood vessels and fibroblasts. In a later phase, the wound contracts, the tissue is replaced by mature connective tissue produced by activated fibroblasts, and a scar is formed. All cells involved communicate directly with the ECM by integrins and other matrix receptors. These transmit signals and induce adaptive responses to the environment by the embedded cells. The ECM or proteolytic fragments of individual ECM constituents exert defined biological activities influencing cell survival, differentiation of myofibroblasts, ECM synthesis and turnover, wound angiogenesis and scar remodeling. Extensive crosstalk exists between ECM and growth factors, and between growth factors and integrins. ECM-cell contact also enables direct transmission of mechanical tension, which then modulates many activities of all cellular players. Understanding this complex interplay is important to provide a basis for designing effective wound therapy and for strategic interference with mechanisms that have gone out of control in fibrotic conditions.

Mendeley readers

The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 1%
France 2 <1%
India 2 <1%
Canada 1 <1%
Australia 1 <1%
China 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 193 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 20%
Student > Master 34 17%
Researcher 30 15%
Student > Bachelor 28 14%
Student > Doctoral Student 14 7%
Other 31 15%
Unknown 26 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 24%
Medicine and Dentistry 40 20%
Biochemistry, Genetics and Molecular Biology 39 19%
Engineering 14 7%
Pharmacology, Toxicology and Pharmaceutical Science 10 5%
Other 24 12%
Unknown 29 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2015.
All research outputs
#3,325,679
of 4,689,255 outputs
Outputs from Fibrogenesis & Tissue Repair
#29
of 44 outputs
Outputs of similar age
#40,460
of 59,224 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#2
of 2 outputs
Altmetric has tracked 4,689,255 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 44 research outputs from this source. They receive a mean Attention Score of 2.2. This one scored the same or higher as 15 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,224 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.