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A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations

Overview of attention for article published in BMC Bioinformatics, March 2014
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2 X users

Citations

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Title
A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations
Published in
BMC Bioinformatics, March 2014
DOI 10.1186/1471-2105-15-86
Pubmed ID
Authors

Gregory A Ryslik, Yuwei Cheng, Kei-Hoi Cheung, Yorgo Modis, Hongyu Zhao

Abstract

It is well known that the development of cancer is caused by the accumulation of somatic mutations within the genome. For oncogenes specifically, current research suggests that there is a small set of "driver" mutations that are primarily responsible for tumorigenesis. Further, due to recent pharmacological successes in treating these driver mutations and their resulting tumors, a variety of approaches have been developed to identify potential driver mutations using methods such as machine learning and mutational clustering. We propose a novel methodology that increases our power to identify mutational clusters by taking into account protein tertiary structure via a graph theoretical approach.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 4%
Brazil 1 1%
Germany 1 1%
Spain 1 1%
Japan 1 1%
Unknown 65 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 28%
Student > Master 10 14%
Researcher 6 8%
Student > Postgraduate 5 7%
Student > Doctoral Student 5 7%
Other 15 21%
Unknown 11 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 31%
Computer Science 11 15%
Biochemistry, Genetics and Molecular Biology 9 13%
Engineering 5 7%
Medicine and Dentistry 3 4%
Other 10 14%
Unknown 12 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2014.
All research outputs
#17,716,357
of 22,749,166 outputs
Outputs from BMC Bioinformatics
#5,925
of 7,268 outputs
Outputs of similar age
#155,135
of 224,560 outputs
Outputs of similar age from BMC Bioinformatics
#73
of 100 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,268 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,560 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.