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Evidence for genetic association of RORB with bipolar disorder

Overview of attention for article published in BMC Psychiatry, November 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

blogs
2 blogs
facebook
1 Facebook page

Citations

dimensions_citation
93 Dimensions

Readers on

mendeley
105 Mendeley
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Title
Evidence for genetic association of RORB with bipolar disorder
Published in
BMC Psychiatry, November 2009
DOI 10.1186/1471-244x-9-70
Pubmed ID
Authors

Casey L McGrath, Stephen J Glatt, Pamela Sklar, Helen Le-Niculescu, Ronald Kuczenski, Alysa E Doyle, Joseph Biederman, Eric Mick, Stephen V Faraone, Alexander B Niculescu, Ming T Tsuang

Abstract

Bipolar disorder, particularly in children, is characterized by rapid cycling and switching, making circadian clock genes plausible molecular underpinnings for bipolar disorder. We previously reported work establishing mice lacking the clock gene D-box binding protein (DBP) as a stress-reactive genetic animal model of bipolar disorder. Microarray studies revealed that expression of two closely related clock genes, RAR-related orphan receptors alpha (RORA) and beta (RORB), was altered in these mice. These retinoid-related receptors are involved in a number of pathways including neurogenesis, stress response, and modulation of circadian rhythms. Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Turkey 1 <1%
Netherlands 1 <1%
Greece 1 <1%
Unknown 100 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 18%
Student > Ph. D. Student 13 12%
Student > Master 10 10%
Student > Bachelor 9 9%
Professor 8 8%
Other 30 29%
Unknown 16 15%
Readers by discipline Count As %
Medicine and Dentistry 27 26%
Agricultural and Biological Sciences 24 23%
Psychology 11 10%
Neuroscience 9 9%
Biochemistry, Genetics and Molecular Biology 8 8%
Other 8 8%
Unknown 18 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2012.
All research outputs
#2,527,763
of 22,649,029 outputs
Outputs from BMC Psychiatry
#904
of 4,628 outputs
Outputs of similar age
#9,177
of 93,152 outputs
Outputs of similar age from BMC Psychiatry
#2
of 13 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,628 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,152 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.