Title |
Evidence for genetic association of RORB with bipolar disorder
|
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Published in |
BMC Psychiatry, November 2009
|
DOI | 10.1186/1471-244x-9-70 |
Pubmed ID | |
Authors |
Casey L McGrath, Stephen J Glatt, Pamela Sklar, Helen Le-Niculescu, Ronald Kuczenski, Alysa E Doyle, Joseph Biederman, Eric Mick, Stephen V Faraone, Alexander B Niculescu, Ming T Tsuang |
Abstract |
Bipolar disorder, particularly in children, is characterized by rapid cycling and switching, making circadian clock genes plausible molecular underpinnings for bipolar disorder. We previously reported work establishing mice lacking the clock gene D-box binding protein (DBP) as a stress-reactive genetic animal model of bipolar disorder. Microarray studies revealed that expression of two closely related clock genes, RAR-related orphan receptors alpha (RORA) and beta (RORB), was altered in these mice. These retinoid-related receptors are involved in a number of pathways including neurogenesis, stress response, and modulation of circadian rhythms. Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
Turkey | 1 | <1% |
Netherlands | 1 | <1% |
Greece | 1 | <1% |
Unknown | 100 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 18% |
Student > Ph. D. Student | 13 | 12% |
Student > Master | 10 | 10% |
Student > Bachelor | 9 | 9% |
Professor | 8 | 8% |
Other | 30 | 29% |
Unknown | 16 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 26% |
Agricultural and Biological Sciences | 24 | 23% |
Psychology | 11 | 10% |
Neuroscience | 9 | 9% |
Biochemistry, Genetics and Molecular Biology | 8 | 8% |
Other | 8 | 8% |
Unknown | 18 | 17% |