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Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine

Overview of attention for article published in Malaria Journal, March 2014
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Title
Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine
Published in
Malaria Journal, March 2014
DOI 10.1186/1475-2875-13-96
Pubmed ID
Authors

Chanthap Lon, Michele Spring, Somethy Sok, Soklyda Chann, Rathvichet Bun, Mali Ittiverakul, Nillawan Buathong, Khengheng Thay, Nareth Kong, Yom You, Worachet Kuntawunginn, Charlotte A Lanteri, David L Saunders

Abstract

The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine or piperaquine to cause oxidant haemolysis is believed to be much lower, particularly during treatment of uncomplicated malaria. Here is an unusual case of BWF, which developed on day 2 of treatment for uncomplicated Plasmodium falciparum infection with dihydroartemisinin-piperaquine (DHA-PIP) with documented evidence of concomitant seropositivity for Chikungunya infection.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United Kingdom 1 2%
United States 1 2%
Unknown 52 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 15%
Student > Bachelor 8 15%
Student > Postgraduate 6 11%
Student > Master 6 11%
Student > Ph. D. Student 4 7%
Other 13 24%
Unknown 10 18%
Readers by discipline Count As %
Medicine and Dentistry 24 44%
Biochemistry, Genetics and Molecular Biology 3 5%
Agricultural and Biological Sciences 3 5%
Arts and Humanities 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 8 15%
Unknown 13 24%